Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography. Export

@article{citeulike:2340701, abstract = {The regional binding of N1'-([11C]methyl)naltrindole (MeNTI), a selective delta-opioid antagonist, was studied in healthy human subjects with positron emission tomography (PET). After the bolus intravenous administration of high specific activity [11C]MeNTI, PET was performed over 90 minutes. Arterial plasma samples were obtained during the scanning period and assayed for the presence of radiolabeled metabolites. The data were analyzed with various kinetic (two- and three-compartment models, Patlak graphical analysis) and nonkinetic (apparent volume of distribution and activity at a late scanning time) approaches. This tracer showed irreversible binding characteristics during the scanning period used. The results of the analyses also were compared with the density and distribution of delta-opioid receptors in the human brain in vitro. Additionally, computer simulations were performed to assess the effects of changes in receptor binding and tracer transport changes on the perceived binding parameters obtained with the models. A constrained three-compartment kinetic model was demonstrated to be superior to other quantification models for the description of MeNTI kinetics and quantification of delta receptor binding in the human brain with 11C-labeled MeNTI.}, address = {Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.}, author = {Smith, J. S. and Zubieta, J. K. and Price, J. C. and Flesher, J. E. and Madar, I. and Lever, J. R. and Kinter, C. M. and Dannals, R. F. and Frost, J. J.}, citeulike-article-id = {2340701}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/00004647-199909000-00003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10478647}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10478647}, doi = {10.1097/00004647-199909000-00003}, issn = {0271-678X}, journal = {J Cereb Blood Flow Metab}, keywords = {human, opioid}, month = {September}, number = {9}, pages = {956--966}, posted-at = {2008-02-06 11:32:37}, priority = {0}, title = {Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography.}, url = {http://dx.doi.org/10.1097/00004647-199909000-00003}, volume = {19}, year = {1999} }

TY - JOUR ID - citeulike:2340701 L3 - citeulike-article-id:2340701 N2 - The regional binding of N1'-([11C]methyl)naltrindole (MeNTI), a selective delta-opioid antagonist, was studied in healthy human subjects with positron emission tomography (PET). After the bolus intravenous administration of high specific activity [11C]MeNTI, PET was performed over 90 minutes. Arterial plasma samples were obtained during the scanning period and assayed for the presence of radiolabeled metabolites. The data were analyzed with various kinetic (two- and three-compartment models, Patlak graphical analysis) and nonkinetic (apparent volume of distribution and activity at a late scanning time) approaches. This tracer showed irreversible binding characteristics during the scanning period used. The results of the analyses also were compared with the density and distribution of delta-opioid receptors in the human brain in vitro. Additionally, computer simulations were performed to assess the effects of changes in receptor binding and tracer transport changes on the perceived binding parameters obtained with the models. A constrained three-compartment kinetic model was demonstrated to be superior to other quantification models for the description of MeNTI kinetics and quantification of delta receptor binding in the human brain with 11C-labeled MeNTI. IS - 9 JF - J Cereb Blood Flow Metab SN - 0271-678X AD - Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. EP - 966 TI - Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography. VL - 19 SP - 956 KW - human KW - opioid AU - Smith, JS AU - Zubieta, JK AU - Price, JC AU - Flesher, JE AU - Madar, I AU - Lever, JR AU - Kinter, CM AU - Dannals, RF AU - Frost, JJ PY - 1999/09// UR - http://dx.doi.org/10.1097/00004647-199909000-00003 ER -