The effect of dendritic topology on firing patterns in model neurons. Export

@article{citeulike:2619660, abstract = {Neuronal firing patterns are influenced by both membrane properties and dendritic morphology. Distinguishing two sources of morphological variability-metrics and topology-we investigate the extent to which model neurons that have the same metrical and membrane properties can still produce different firing patterns as a result of differences in dendritic topology. Within a set of dendritic trees that have the same number of terminal segments and the same total dendritic length, we show that firing frequency strongly correlates with topology as expressed by the mean dendritic path length. The effect of dendritic topology on firing frequency is bigger for trees with equal segment diameters than for trees whose segment diameters obey Rall's 3/2 power law. If active dendritic channels are present, dendritic topology influences not only firing frequency but also type of firing (regular, bursting).}, address = {Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam.}, author = {van Ooyen, A. and Duijnhouwer, J. and Remme, M. W. and van Pelt, J.}, citeulike-article-id = {2619660}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12222816}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12222816}, issn = {0954-898X}, journal = {Network}, keywords = {neuronal\_networks, simulation}, month = {August}, number = {3}, pages = {311--325}, posted-at = {2008-04-01 13:47:54}, priority = {2}, title = {The effect of dendritic topology on firing patterns in model neurons.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12222816}, volume = {13}, year = {2002} }

TY - JOUR ID - citeulike:2619660 L3 - citeulike-article-id:2619660 N2 - Neuronal firing patterns are influenced by both membrane properties and dendritic morphology. Distinguishing two sources of morphological variability-metrics and topology-we investigate the extent to which model neurons that have the same metrical and membrane properties can still produce different firing patterns as a result of differences in dendritic topology. Within a set of dendritic trees that have the same number of terminal segments and the same total dendritic length, we show that firing frequency strongly correlates with topology as expressed by the mean dendritic path length. The effect of dendritic topology on firing frequency is bigger for trees with equal segment diameters than for trees whose segment diameters obey Rall's 3/2 power law. If active dendritic channels are present, dendritic topology influences not only firing frequency but also type of firing (regular, bursting). IS - 3 JF - Network SN - 0954-898X AD - Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam. EP - 325 TI - The effect of dendritic topology on firing patterns in model neurons. VL - 13 SP - 311 KW - neuronal_networks KW - simulation AU - van Ooyen, A AU - Duijnhouwer, J AU - Remme, MW AU - van Pelt, J PY - 2002/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/12222816 ER -