Genome analysis of the platypus reveals unique signatures of evolution Export

@article{citeulike:2767706, abstract = {We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.}, citeulike-article-id = {2767706}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature06936}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature06936}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18464734}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18464734}, day = {08}, doi = {10.1038/nature06936}, issn = {0028-0836}, journal = {Nature}, keywords = {evolution, genome}, month = {May}, number = {7192}, pages = {175--183}, posted-at = {2008-05-14 11:15:16}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genome analysis of the platypus reveals unique signatures of evolution}, url = {http://dx.doi.org/10.1038/nature06936}, volume = {453}, year = {2008} }

TY - JOUR ID - citeulike:2767706 L3 - citeulike-article-id:2767706 N2 - We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation. IS - 7192 JF - Nature SN - 0028-0836 EP - 183 TI - Genome analysis of the platypus reveals unique signatures of evolution PB - Nature Publishing Group VL - 453 SP - 175 KW - evolution KW - genome PY - 2008/05/08/ UR - http://dx.doi.org/10.1038/nature06936 ER -