The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation Export

@article{citeulike:2822866, abstract = {Endocannabinoids are retrograde neurotransmitters, which act upon the presynaptically located, G-protein coupled receptor CB1, to modulate synaptic transmission in the adult brain. Recently, however, a number of lines of evidence have suggested that endocannabinoid signalling may play an important role in early neuronal development. In this study, we show that the CB1 receptor has a wide expression pattern in the developing nervous system and that its expression follows neuronal differentiation in the embryo from the earliest stages. We also show that the enzymes involved in 2-AG synthesis are expressed in an overlapping manner at these stages. We further show that interfering with CB1 function using a pharmacological inhibitor causes problems in axon pathfinding and fasciculation. Similarly, CB1 gene knock down in the zebrafish by morpholino injection results in defects in axonal growth and fasciculation in these embryos. Thus CB1 function is required in the early embryo for axonal growth and fasciculation.}, author = {Watson, Sheona and Chambers, David and Hobbs, Carl and Doherty, Patrick and Graham, Anthony}, citeulike-article-id = {2822866}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mcn.2008.02.001}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WNB-4S1C8CD-1/1/c66b256a159b6d8e9e02e75d908ee3e2}, doi = {10.1016/j.mcn.2008.02.001}, journal = {Molecular and Cellular Neuroscience}, keywords = {cb1}, month = {May}, number = {1}, pages = {89--97}, posted-at = {2008-05-22 12:25:38}, priority = {2}, title = {The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation}, url = {http://dx.doi.org/10.1016/j.mcn.2008.02.001}, volume = {38}, year = {2008} }

TY - JOUR ID - citeulike:2822866 L3 - citeulike-article-id:2822866 N2 - Endocannabinoids are retrograde neurotransmitters, which act upon the presynaptically located, G-protein coupled receptor CB1, to modulate synaptic transmission in the adult brain. Recently, however, a number of lines of evidence have suggested that endocannabinoid signalling may play an important role in early neuronal development. In this study, we show that the CB1 receptor has a wide expression pattern in the developing nervous system and that its expression follows neuronal differentiation in the embryo from the earliest stages. We also show that the enzymes involved in 2-AG synthesis are expressed in an overlapping manner at these stages. We further show that interfering with CB1 function using a pharmacological inhibitor causes problems in axon pathfinding and fasciculation. Similarly, CB1 gene knock down in the zebrafish by morpholino injection results in defects in axonal growth and fasciculation in these embryos. Thus CB1 function is required in the early embryo for axonal growth and fasciculation. IS - 1 JF - Molecular and Cellular Neuroscience EP - 97 TI - The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation VL - 38 SP - 89 KW - cb1 AU - Watson, Sheona AU - Chambers, David AU - Hobbs, Carl AU - Doherty, Patrick AU - Graham, Anthony PY - 2008/05// UR - http://dx.doi.org/10.1016/j.mcn.2008.02.001 ER -