Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol Export

@article{Chakraborty1995, abstract = {Peptide 23 was first identified in pituitary cell conditioned medium as a secreted protein which was regulated in a similar fashion to growth hormone. It was subsequently found to be a member of the C-type lectin gene superfamily and identical to pancreatis associated protein (PAP). It is widely expressed in the gastrointestinal tract. Our present study demonstrates that peptide 23 gene is also expressed in the uterus. Peptide 23/PAP mRNA was at highest levels during estrus and was not detectable in the immature rat uterus. A single injection of 17[beta]-estradiol resulted in a transient induction of peptide 23/PAP mRNA in ovariectomized rats whereas a sustained induction was seen with diethylstilbestrol implants. In situ hybridization localized peptide 23/PAP mRNA to the luminal epithelial cells. During gestation, peptide 23/PAP mRNA was detected only in the uterine samples from day 12 to 18 of pregnancy with maximal expression on day 12. Peptide 23 expression was confined to the uterus itself and not expressed in either the decidua or the fetal tissues. PSP/reg, another closely related member of the C-lectin gene family was not expressed in any of these uterine tissues. These results indicate that estrogen may act as a physiological regulator of peptide 23 in the uterus and suggests that this protein may have some role in estrogen action.}, author = {Chakraborty, C. and Vrontakis, M. and Molnar, P. and Schroedter, I. C. and Katsumata, N. and Murphy, L. J. and Shiu, R. P. C. and Friesen, H. G.}, citeulike-article-id = {1217886}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0303-7207(94)03470-E}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T3G-3XVH3JJ-1M/2/bef5402bf7cd8c57ff317d25139a772e}, day = {27}, doi = {10.1016/0303-7207(94)03470-E}, journal = {Molecular and Cellular Endocrinology}, keywords = {expression, pap}, month = {February}, number = {1-2}, pages = {149--154}, posted-at = {2007-04-09 14:23:33}, priority = {2}, title = {Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol}, url = {http://dx.doi.org/10.1016/0303-7207(94)03470-E}, volume = {108}, year = {1995} }

TY - JOUR ID - Chakraborty1995 L3 - citeulike-article-id:1217886 N2 - Peptide 23 was first identified in pituitary cell conditioned medium as a secreted protein which was regulated in a similar fashion to growth hormone. It was subsequently found to be a member of the C-type lectin gene superfamily and identical to pancreatis associated protein (PAP). It is widely expressed in the gastrointestinal tract. Our present study demonstrates that peptide 23 gene is also expressed in the uterus. Peptide 23/PAP mRNA was at highest levels during estrus and was not detectable in the immature rat uterus. A single injection of 17[beta]-estradiol resulted in a transient induction of peptide 23/PAP mRNA in ovariectomized rats whereas a sustained induction was seen with diethylstilbestrol implants. In situ hybridization localized peptide 23/PAP mRNA to the luminal epithelial cells. During gestation, peptide 23/PAP mRNA was detected only in the uterine samples from day 12 to 18 of pregnancy with maximal expression on day 12. Peptide 23 expression was confined to the uterus itself and not expressed in either the decidua or the fetal tissues. PSP/reg, another closely related member of the C-lectin gene family was not expressed in any of these uterine tissues. These results indicate that estrogen may act as a physiological regulator of peptide 23 in the uterus and suggests that this protein may have some role in estrogen action. IS - 1-2 JF - Molecular and Cellular Endocrinology EP - 154 TI - Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol VL - 108 SP - 149 KW - expression KW - pap AU - Chakraborty, C AU - Vrontakis, M AU - Molnar, P AU - Schroedter, IC AU - Katsumata, N AU - Murphy, LJ AU - Shiu, RPC AU - Friesen, HG PY - 1995/02/27/ UR - http://dx.doi.org/10.1016/0303-7207(94)03470-E ER -