Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Export

@article{citeulike:2315306, abstract = {The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1 alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.}, address = {Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.}, author = {Zhong, Z. and Wen, Z. and Darnell, J. E.}, citeulike-article-id = {2315306}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8140422}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8140422}, day = {1}, issn = {0036-8075}, journal = {Science}, keywords = {il-6, il6, stat}, month = {April}, number = {5155}, pages = {95--98}, posted-at = {2008-01-31 15:42:52}, priority = {2}, title = {Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8140422}, volume = {264}, year = {1994} }

TY - JOUR ID - citeulike:2315306 L3 - citeulike-article-id:2315306 N2 - The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1 alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface. IS - 5155 JF - Science SN - 0036-8075 AD - Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021. EP - 98 TI - Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. VL - 264 SP - 95 KW - il-6 KW - il6 KW - stat AU - Zhong, Z AU - Wen, Z AU - Darnell, JE PY - 1994/04/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8140422 ER -