Resistin-like molecule [beta] regulates innate colonic function: Barrier integrity and inflammation susceptibility Export

@article{Hogan2006, abstract = {BackgroundResistin-like molecule (RELM) [beta] is a cysteine-rich cytokine expressed in the gastrointestinal tract and implicated in insulin resistance and gastrointestinal nematode immunity; however, its function primarily remains an enigma.ObjectiveWe sought to elucidate the function of RELM-[beta] in the gastrointestinal tract.MethodsWe generated RELM-[beta] gene-targeted mice and examined colonic epithelial barrier function, gene expression profiles, and susceptibility to acute colonic inflammation.ResultsWe show that RELM-[beta] is constitutively expressed in the colon by goblet cells and enterocytes and has a role in homeostasis, as assessed by alterations in colon mRNA transcripts and epithelial barrier function in the absence of RELM-[beta]. Using acute colonic inflammatory models, we demonstrate that RELM-[beta] has a central role in the regulation of susceptibility to colonic inflammation. Mechanistic studies identify that RELM-[beta] regulates expression of type III regenerating gene (REG) (REG3[beta] and [gamma]), molecules known to influence nuclear factor [kappa]B signaling.ConclusionsThese data define a critical role for RELM-[beta] in the maintenance of colonic barrier function and gastrointestinal innate immunity.Clinical implicationsThese findings identify RELM-[beta] as an important molecule in homeostatic gastrointestinal function and colonic inflammation, and as such, these results have implications for a variety of human inflammatory gastrointestinal conditions, including allergic gastroenteropathies.}, author = {Hogan, Simon P. and Seidu, Luqman and Blanchard, Carine and Groschwitz, Katherine and Mishra, Anil and Karow, Margaret L. and Ahrens, Richard and Artis, David and Murphy, Andrew J. and Valenzuela, David M.}, citeulike-article-id = {780908}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jaci.2006.04.039}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WH4-4K991BW-R/2/282c1e33cf5e8408ddc4ed050a66731d}, doi = {10.1016/j.jaci.2006.04.039}, journal = {Journal of Allergy and Clinical Immunology}, keywords = {barrier, inflammation}, month = {July}, number = {1}, pages = {257--268}, posted-at = {2006-07-31 11:44:10}, priority = {2}, title = {Resistin-like molecule [beta] regulates innate colonic function: Barrier integrity and inflammation susceptibility}, url = {http://dx.doi.org/10.1016/j.jaci.2006.04.039}, volume = {118}, year = {2006} }

TY - JOUR ID - Hogan2006 L3 - citeulike-article-id:780908 N2 - BackgroundResistin-like molecule (RELM) [beta] is a cysteine-rich cytokine expressed in the gastrointestinal tract and implicated in insulin resistance and gastrointestinal nematode immunity; however, its function primarily remains an enigma.ObjectiveWe sought to elucidate the function of RELM-[beta] in the gastrointestinal tract.MethodsWe generated RELM-[beta] gene-targeted mice and examined colonic epithelial barrier function, gene expression profiles, and susceptibility to acute colonic inflammation.ResultsWe show that RELM-[beta] is constitutively expressed in the colon by goblet cells and enterocytes and has a role in homeostasis, as assessed by alterations in colon mRNA transcripts and epithelial barrier function in the absence of RELM-[beta]. Using acute colonic inflammatory models, we demonstrate that RELM-[beta] has a central role in the regulation of susceptibility to colonic inflammation. Mechanistic studies identify that RELM-[beta] regulates expression of type III regenerating gene (REG) (REG3[beta] and [gamma]), molecules known to influence nuclear factor [kappa]B signaling.ConclusionsThese data define a critical role for RELM-[beta] in the maintenance of colonic barrier function and gastrointestinal innate immunity.Clinical implicationsThese findings identify RELM-[beta] as an important molecule in homeostatic gastrointestinal function and colonic inflammation, and as such, these results have implications for a variety of human inflammatory gastrointestinal conditions, including allergic gastroenteropathies. IS - 1 JF - Journal of Allergy and Clinical Immunology EP - 268 TI - Resistin-like molecule [beta] regulates innate colonic function: Barrier integrity and inflammation susceptibility VL - 118 SP - 257 KW - barrier KW - inflammation AU - Hogan, Simon AU - Seidu, Luqman AU - Blanchard, Carine AU - Groschwitz, Katherine AU - Mishra, Anil AU - Karow, Margaret AU - Ahrens, Richard AU - Artis, David AU - Murphy, Andrew AU - Valenzuela, David PY - 2006/07// UR - http://dx.doi.org/10.1016/j.jaci.2006.04.039 ER -