The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. Export

@article{Cao2006, abstract = {Lesioning the peripheral branch of a dorsal root ganglion (DRG) neuron before injury of the central branch of the same neuron enables spontaneous regeneration of these spinal axons. This effect is cAMP and transcription dependent. Here, we show that the cytokine interleukin-6 (IL-6) is upregulated in DRG neurons after either a conditioning lesion or treatment with dibutyryl-cAMP. In culture, IL-6 allows neurons to grow in the presence of inhibitors of regeneration present in myelin. Importantly, intrathecal delivery of IL-6 to DRG neurons blocks inhibition by myelin both in vitro and in vivo, effectively mimicking the conditioning lesion. Blocking IL-6 signaling has no effect on the ability of cAMP to overcome myelin inhibitors. Consistent with this, IL-6-deficient mice respond to a conditioning lesion as effectively as wild-type mice. We conclude that IL-6 can mimic both the cAMP effect and the conditioning lesion effect but is not an essential component of either response.}, address = {Department of Biological Sciences, Hunter College, The City University of New York, New York, New York 10021, USA.}, author = {Cao, Z. and Gao, Y. and Bryson, J. B. and Hou, J. and Chaudhry, N. and Siddiq, M. and Martinez, J. and Spencer, T. and Carmel, J. and Hart, R. B. and Filbin, M. T.}, citeulike-article-id = {786011}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.0815-06.2006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16707807}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16707807}, day = {17}, doi = {10.1523/JNEUROSCI.0815-06.2006}, issn = {1529-2401}, journal = {J Neurosci}, keywords = {axonal, function, gfap, growth, il6}, month = {May}, number = {20}, pages = {5565--5573}, posted-at = {2006-08-04 11:20:46}, priority = {2}, title = {The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.0815-06.2006}, volume = {26}, year = {2006} }

TY - JOUR ID - Cao2006 L3 - citeulike-article-id:786011 N2 - Lesioning the peripheral branch of a dorsal root ganglion (DRG) neuron before injury of the central branch of the same neuron enables spontaneous regeneration of these spinal axons. This effect is cAMP and transcription dependent. Here, we show that the cytokine interleukin-6 (IL-6) is upregulated in DRG neurons after either a conditioning lesion or treatment with dibutyryl-cAMP. In culture, IL-6 allows neurons to grow in the presence of inhibitors of regeneration present in myelin. Importantly, intrathecal delivery of IL-6 to DRG neurons blocks inhibition by myelin both in vitro and in vivo, effectively mimicking the conditioning lesion. Blocking IL-6 signaling has no effect on the ability of cAMP to overcome myelin inhibitors. Consistent with this, IL-6-deficient mice respond to a conditioning lesion as effectively as wild-type mice. We conclude that IL-6 can mimic both the cAMP effect and the conditioning lesion effect but is not an essential component of either response. IS - 20 JF - J Neurosci SN - 1529-2401 AD - Department of Biological Sciences, Hunter College, The City University of New York, New York, New York 10021, USA. EP - 5573 TI - The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. VL - 26 SP - 5565 KW - axonal KW - function KW - gfap KW - growth KW - il6 AU - Cao, Z AU - Gao, Y AU - Bryson, JB AU - Hou, J AU - Chaudhry, N AU - Siddiq, M AU - Martinez, J AU - Spencer, T AU - Carmel, J AU - Hart, RB AU - Filbin, MT PY - 2006/05/17/ UR - http://dx.doi.org/10.1523/JNEUROSCI.0815-06.2006 ER -