Alzheimer's disease is a synaptic failure. Export

@article{Selkoe2002, abstract = {In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.}, author = {Selkoe, Dennis J.}, citeulike-article-id = {808613}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1074069}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/298/5594/789}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12399581}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12399581}, day = {25}, doi = {10.1126/science.1074069}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {alzheimer}, month = {October}, number = {5594}, pages = {789--791}, posted-at = {2006-08-20 10:56:27}, priority = {2}, title = {Alzheimer's disease is a synaptic failure.}, url = {http://dx.doi.org/10.1126/science.1074069}, volume = {298}, year = {2002} }

TY - JOUR ID - Selkoe2002 L3 - citeulike-article-id:808613 N2 - In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein. IS - 5594 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 791 TI - Alzheimer's disease is a synaptic failure. VL - 298 SP - 789 KW - alzheimer AU - Selkoe, Dennis PY - 2002/10/25/ UR - http://dx.doi.org/10.1126/science.1074069 ER -