Phosphoinositide 3-kinase in T cell activation and survival. Export

@article{citeulike:466958, abstract = {PI3Ks (phosphoinositide 3-kinases) regulate diverse signalling pathways involved in growth, proliferation, survival, differentiation and metabolism. In T cells, PI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors, cytokine receptors and chemokine receptors. However, the specific roles of PI3Ks downstream of these receptors vary. An inactivating mutation in the leucocyte-specific PI3K isoform p110delta results in impaired TcR-dependent proliferation under circumstances where CD28 co-stimulation is blocked or not required. Recruitment and activation of PI3K by CD28 promotes survival by inducing increased expression of Bcl-X(L). However, CD28 engages additional signals that regulate proliferation and interleukin-2 production independently of PI3K. Thus a model emerges whereby PI3K is involved in both TcR and CD28 signalling, but each receptor may only exploit a subset of the signalling pathways potentially controlled by PI3K activation.}, address = {Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, Babraham Institute, Cambridge CB2 4AT, U.K. klaus.okkenhaug@bbsrc.ac.uk}, author = {Okkenhaug, K. and Bilancio, A. and Emery, J. L. and Vanhaesebroeck, B.}, citeulike-article-id = {466958}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15046602}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15046602}, comment = {reaction 96}, issn = {0300-5127}, journal = {Biochem Soc Trans}, keywords = {pi3k, tcrmr}, month = {April}, number = {Pt 2}, pages = {332--335}, posted-at = {2006-06-28 11:38:39}, priority = {5}, title = {Phosphoinositide 3-kinase in T cell activation and survival.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15046602}, volume = {32}, year = {2004} }

TY - JOUR ID - citeulike:466958 L3 - citeulike-article-id:466958 N2 - PI3Ks (phosphoinositide 3-kinases) regulate diverse signalling pathways involved in growth, proliferation, survival, differentiation and metabolism. In T cells, PI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors, cytokine receptors and chemokine receptors. However, the specific roles of PI3Ks downstream of these receptors vary. An inactivating mutation in the leucocyte-specific PI3K isoform p110delta results in impaired TcR-dependent proliferation under circumstances where CD28 co-stimulation is blocked or not required. Recruitment and activation of PI3K by CD28 promotes survival by inducing increased expression of Bcl-X(L). However, CD28 engages additional signals that regulate proliferation and interleukin-2 production independently of PI3K. Thus a model emerges whereby PI3K is involved in both TcR and CD28 signalling, but each receptor may only exploit a subset of the signalling pathways potentially controlled by PI3K activation. IS - Pt 2 JF - Biochem Soc Trans SN - 0300-5127 AD - Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, Babraham Institute, Cambridge CB2 4AT, U.K. klaus.okkenhaug@bbsrc.ac.uk EP - 335 TI - Phosphoinositide 3-kinase in T cell activation and survival. VL - 32 SP - 332 KW - pi3k KW - tcrmr N1 - reaction 96 AU - Okkenhaug, K AU - Bilancio, A AU - Emery, JL AU - Vanhaesebroeck, B PY - 2004/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/15046602 ER -