Structure, regulation and function of PKB/AKT--a major therapeutic target Export

@article{citeulike:713488, abstract = {Protein phosphorylation and dephosphorylation play a major role in intracellular signal transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player in the signal transduction pathways activated in response to growth factors or insulin and is thought to contribute to several cellular functions including nutrient metabolism, cell growth and apoptosis. Recently, several significant publications have described novel mechanisms used to regulate PKB. Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics.}, author = {Hanada, Masahito and Feng, Jianhua and Hemmings, Brian A.}, booktitle = {IPK'2003. Inhibitors of protein kinases and Workshop: Phosphoryl-transfer mechanisms}, citeulike-article-id = {713488}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbapap.2003.11.009}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B73DJ-4B5R93M-7/2/4025d672702b139861e85df5e55f8f78}, comment = {references 82-86}, day = {11}, doi = {10.1016/j.bbapap.2003.11.009}, journal = {Biochimica et Biophysica Acta (BBA) - Proteins \& Proteomics}, keywords = {pkb-3, tcrmr}, month = {March}, number = {1-2}, pages = {3--16}, posted-at = {2006-06-28 13:14:03}, priority = {2}, title = {Structure, regulation and function of PKB/AKT--a major therapeutic target}, url = {http://dx.doi.org/10.1016/j.bbapap.2003.11.009}, volume = {1697}, year = {2004} }

TY - JOUR ID - citeulike:713488 L3 - citeulike-article-id:713488 N2 - Protein phosphorylation and dephosphorylation play a major role in intracellular signal transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player in the signal transduction pathways activated in response to growth factors or insulin and is thought to contribute to several cellular functions including nutrient metabolism, cell growth and apoptosis. Recently, several significant publications have described novel mechanisms used to regulate PKB. Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics. IS - 1-2 JF - Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics EP - 16 TI - Structure, regulation and function of PKB/AKT--a major therapeutic target VL - 1697 T2 - IPK'2003. Inhibitors of protein kinases and Workshop: Phosphoryl-transfer mechanisms SP - 3 KW - pkb-3 KW - tcrmr N1 - references 82-86 AU - Hanada, Masahito AU - Feng, Jianhua AU - Hemmings, Brian PY - 2004/03/11/ UR - http://dx.doi.org/10.1016/j.bbapap.2003.11.009 ER -