DAVID: Database for Annotation, Visualization, and Integrated Discovery Export

@article{citeulike:2319219, abstract = {BACKGROUND:Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. The distributed nature of biological knowledge frequently requires researchers to navigate through numerous web-accessible databases gathering information one gene at a time. A more judicious approach is to provide query-based access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information.RESULTS:Database for Annotation, Visualization, and Integrated Discovery (DAVID; http://www.david.niaid.nih.gov) addresses this need via four web-based analysis modules: 1) Annotation Tool - rapidly appends descriptive data from several public databases to lists of genes; 2) GoCharts - assigns genes to Gene Ontology functional categories based on user selected classifications and term specificity level; 3) KeggCharts - assigns genes to KEGG metabolic processes and enables users to view genes in the context of biochemical pathway maps; and 4) DomainCharts - groups genes according to PFAM conserved protein domains.CONCLUSIONS:Analysis results and graphical displays remain dynamically linked to primary data and external data repositories, thereby furnishing in-depth as well as broad-based data coverage. The functionality provided by DAVID accelerates the analysis of genome-scale datasets by facilitating the transition from data collection to biological meaning.}, address = {Science Applications International Corporation-Frederick, Clinical Services Program, Laboratory of Immunopathogenesis and Bioinformatics, National Cancer Institute at Frederick, MD 21702, USA. GDennis@niaid.nih.gov}, author = {Dennis, Glynn and Sherman, Brad and Hosack, Douglas and Yang, Jun and Gao, Wei and Lane, H. Clifford and Lempicki, Richard}, citeulike-article-id = {2319219}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2003-4-5-p3}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12734009}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12734009}, doi = {10.1186/gb-2003-4-5-p3}, issn = {1465-6906}, journal = {Genome Biology}, keywords = {bioinformatics, conceptual, microarray, statistics}, number = {5}, pages = {P3+}, posted-at = {2009-06-04 12:32:33}, priority = {2}, title = {DAVID: Database for Annotation, Visualization, and Integrated Discovery}, url = {http://dx.doi.org/10.1186/gb-2003-4-5-p3}, volume = {4}, year = {2003} }

TY - JOUR ID - citeulike:2319219 L3 - citeulike-article-id:2319219 N2 - BACKGROUND:Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. The distributed nature of biological knowledge frequently requires researchers to navigate through numerous web-accessible databases gathering information one gene at a time. A more judicious approach is to provide query-based access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information.RESULTS:Database for Annotation, Visualization, and Integrated Discovery (DAVID; http://www.david.niaid.nih.gov) addresses this need via four web-based analysis modules: 1) Annotation Tool - rapidly appends descriptive data from several public databases to lists of genes; 2) GoCharts - assigns genes to Gene Ontology functional categories based on user selected classifications and term specificity level; 3) KeggCharts - assigns genes to KEGG metabolic processes and enables users to view genes in the context of biochemical pathway maps; and 4) DomainCharts - groups genes according to PFAM conserved protein domains.CONCLUSIONS:Analysis results and graphical displays remain dynamically linked to primary data and external data repositories, thereby furnishing in-depth as well as broad-based data coverage. The functionality provided by DAVID accelerates the analysis of genome-scale datasets by facilitating the transition from data collection to biological meaning. IS - 5 JF - Genome Biology SN - 1465-6906 AD - Science Applications International Corporation-Frederick, Clinical Services Program, Laboratory of Immunopathogenesis and Bioinformatics, National Cancer Institute at Frederick, MD 21702, USA. GDennis@niaid.nih.gov TI - DAVID: Database for Annotation, Visualization, and Integrated Discovery VL - 4 SP - P3 KW - bioinformatics KW - conceptual KW - microarray KW - statistics AU - Dennis, Glynn AU - Sherman, Brad AU - Hosack, Douglas AU - Yang, Jun AU - Gao, Wei AU - Lane, Clifford AU - Lempicki, Richard PY - 2003/// UR - http://dx.doi.org/10.1186/gb-2003-4-5-p3 ER -