Comparative analyses of immunoglobulin genes: surprises and portents. Export

@article{citeulike:4505155, abstract = {The study of immunoglobulin genes in non-mouse and non-human models has shown that different vertebrate groups have evolved distinct methods of generating antibody diversity. By contrast, the development of T cells in the thymus is quite similar in all of the species that have been examined. The three mechanisms by which B cells uniquely modify their immunoglobulin genes -- somatic hypermutation, gene conversion and class switching -- are increasingly believed to share some fundamental mechanisms, which studies in different vertebrate groups have helped (and will continue to help) to resolve. When these mechanisms are better understood, we should be able to look to the constitutive pathways from which they have evolved and perhaps determine whether the rearrangement of variable, diversity and joining antibody gene segments -- V(D)J recombination -- was superimposed on an existing adaptive immune system.}, author = {Flajnik, M. F.}, citeulike-article-id = {4505155}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri889}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12209137}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12209137}, doi = {10.1038/nri889}, issn = {1474-1733}, journal = {Nature reviews. Immunology}, keywords = {antibodies, bcells, immunology, transformation}, month = {September}, number = {9}, pages = {688--698}, posted-at = {2009-05-12 14:47:25}, priority = {2}, title = {Comparative analyses of immunoglobulin genes: surprises and portents.}, url = {http://dx.doi.org/10.1038/nri889}, volume = {2}, year = {2002} }

TY - JOUR ID - citeulike:4505155 L3 - citeulike-article-id:4505155 N2 - The study of immunoglobulin genes in non-mouse and non-human models has shown that different vertebrate groups have evolved distinct methods of generating antibody diversity. By contrast, the development of T cells in the thymus is quite similar in all of the species that have been examined. The three mechanisms by which B cells uniquely modify their immunoglobulin genes -- somatic hypermutation, gene conversion and class switching -- are increasingly believed to share some fundamental mechanisms, which studies in different vertebrate groups have helped (and will continue to help) to resolve. When these mechanisms are better understood, we should be able to look to the constitutive pathways from which they have evolved and perhaps determine whether the rearrangement of variable, diversity and joining antibody gene segments -- V(D)J recombination -- was superimposed on an existing adaptive immune system. IS - 9 JF - Nature reviews. Immunology SN - 1474-1733 EP - 698 TI - Comparative analyses of immunoglobulin genes: surprises and portents. VL - 2 SP - 688 KW - antibodies KW - bcells KW - immunology KW - transformation AU - Flajnik, MF PY - 2002/09// UR - http://dx.doi.org/10.1038/nri889 ER -