Neutral Evolution of Mutational Robustness Export

@inproceedings{citeulike:1107730, abstract = {We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network's adjacency matrix. Moreover, the average number of neutral mutant neighbors per individual is given by the matrix spectral radius. This quantifies the extent to which populations evolve mutational robustness: the insensitivity of the phenotype to mutations. Since the average neutrality is independent of evolutionary parameters---such as, mutation rate, population size, and selective advantage---one can infer global statistics of neutral network topology using simple population data available from {\it in vitro} or {\it in vivo} evolution. Populations evolving on neutral networks of RNA secondary structures show excellent agreement with our theoretical predictions.}, author = {van Nimwegen, E. and Crutchfield, J. P. and Huynen, M.}, booktitle = {eprint arXiv:adap-org/9903006}, citeulike-article-id = {1107730}, citeulike-linkout-0 = {http://adsabs.harvard.edu/cgi-bin/nph-bib_query?bibcode=1999adap.org..3006V}, keywords = {evolution-of-evolution, neutral\_evolution}, month = {March}, pages = {3006+}, posted-at = {2007-02-15 05:47:39}, priority = {4}, title = {Neutral Evolution of Mutational Robustness}, url = {http://adsabs.harvard.edu/cgi-bin/nph-bib_query?bibcode=1999adap.org..3006V}, year = {1999} }

TY - CONF ID - citeulike:1107730 L3 - citeulike-article-id:1107730 N2 - We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network's adjacency matrix. Moreover, the average number of neutral mutant neighbors per individual is given by the matrix spectral radius. This quantifies the extent to which populations evolve mutational robustness: the insensitivity of the phenotype to mutations. Since the average neutrality is independent of evolutionary parameters---such as, mutation rate, population size, and selective advantage---one can infer global statistics of neutral network topology using simple population data available from {\it in vitro} or {\it in vivo} evolution. Populations evolving on neutral networks of RNA secondary structures show excellent agreement with our theoretical predictions. TI - Neutral Evolution of Mutational Robustness T2 - eprint arXiv:adap-org/9903006 SP - 3006 KW - evolution-of-evolution KW - neutral_evolution AU - van Nimwegen, E AU - Crutchfield, JP AU - Huynen, M PY - 1999/March// UR - http://adsabs.harvard.edu/cgi-bin/nph-bib_query?bibcode=1999adap.org..3006V ER -