What recent ribosome structures have revealed about the mechanism of translation Export

@article{citeulike:5961523, abstract = {The high-resolution structures of ribosomal subunits published in 2000 have revolutionized the field of protein translation. They facilitated the determination and interpretation of functional complexes of the ribosome by crystallography and electron microscopy. Knowledge of the precise positions of residues in the ribosome in various states has facilitated increasingly sophisticated biochemical and genetic experiments, as well as the use of new methods such as single-molecule kinetics. In this review, we discuss how the interaction between structural and functional studies over the last decade has led to a deeper understanding of the complex mechanisms underlying translation.}, author = {Schmeing, T. Martin and Ramakrishnan, V.}, citeulike-article-id = {5961523}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08403}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08403}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19838167}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19838167}, day = {18}, doi = {10.1038/nature08403}, issn = {0028-0836}, journal = {Nature}, keywords = {mechanism, review, ribosome, structure, translation}, month = {October}, number = {7268}, pages = {1234--1242}, posted-at = {2009-11-10 13:32:27}, priority = {2}, publisher = {Nature Publishing Group}, title = {What recent ribosome structures have revealed about the mechanism of translation}, url = {http://dx.doi.org/10.1038/nature08403}, volume = {461}, year = {2009} }

TY - JOUR ID - citeulike:5961523 L3 - citeulike-article-id:5961523 N2 - The high-resolution structures of ribosomal subunits published in 2000 have revolutionized the field of protein translation. They facilitated the determination and interpretation of functional complexes of the ribosome by crystallography and electron microscopy. Knowledge of the precise positions of residues in the ribosome in various states has facilitated increasingly sophisticated biochemical and genetic experiments, as well as the use of new methods such as single-molecule kinetics. In this review, we discuss how the interaction between structural and functional studies over the last decade has led to a deeper understanding of the complex mechanisms underlying translation. IS - 7268 JF - Nature SN - 0028-0836 EP - 1242 TI - What recent ribosome structures have revealed about the mechanism of translation PB - Nature Publishing Group VL - 461 SP - 1234 KW - mechanism KW - review KW - ribosome KW - structure KW - translation AU - Schmeing, Martin AU - Ramakrishnan, V PY - 2009/10/18/ UR - http://dx.doi.org/10.1038/nature08403 ER -