Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis Export

@article{citeulike:6021524, abstract = {10.1101/gr.218002 The capabilities of genome-scale metabolic networks can be described through the determination of a set of systemically independent and unique flux maps called extreme pathways. The first study of genome-scale extreme pathways for the simultaneous formation of all nonessential amino acids or ribonucleotides in is presented. Three key results were obtained. First, the extreme pathways for the production of individual amino acids in showed far fewer internal states per external state than previously found in , indicating a more rigid metabolic network. Second, the degree of pathway redundancy in was essentially the same for the production of individual amino acids and linked amino acid sets, but was approximately twice that of the production of the ribonucleotides. Third, the metabolic network of was unable to achieve extensive conversion of amino acids consumed to the set of either nonessential amino acids or ribonucleotides and thus diverted a large portion of its nitrogen to ammonia production, a potentially important result for pH regulation in its acidic habitat. Genome-scale extreme pathways elucidate emergent system-wide properties. Extreme pathway analysis is emerging as a potentially important method to analyze the link between the metabolic genotype and its phenotypes.}, author = {Price, Nathan D. and Papin, Jason A. and Palsson, Bernhard}, citeulike-article-id = {6021524}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.218002}, citeulike-linkout-1 = {http://genome.cshlp.org/content/12/5/760.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/12/5/760.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/11997342}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=11997342}, day = {1}, doi = {10.1101/gr.218002}, journal = {Genome Research}, keywords = {analysis, cysteine, extreme, genome-scale, helicobacter, metabolic, network, pathway, properties, pylori, redundancy, systems}, month = {May}, number = {5}, pages = {760--769}, posted-at = {2009-10-28 18:07:09}, priority = {2}, title = {Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis}, url = {http://dx.doi.org/10.1101/gr.218002}, volume = {12}, year = {2002} }

TY - JOUR ID - citeulike:6021524 L3 - citeulike-article-id:6021524 N2 - 10.1101/gr.218002 The capabilities of genome-scale metabolic networks can be described through the determination of a set of systemically independent and unique flux maps called extreme pathways. The first study of genome-scale extreme pathways for the simultaneous formation of all nonessential amino acids or ribonucleotides in is presented. Three key results were obtained. First, the extreme pathways for the production of individual amino acids in showed far fewer internal states per external state than previously found in , indicating a more rigid metabolic network. Second, the degree of pathway redundancy in was essentially the same for the production of individual amino acids and linked amino acid sets, but was approximately twice that of the production of the ribonucleotides. Third, the metabolic network of was unable to achieve extensive conversion of amino acids consumed to the set of either nonessential amino acids or ribonucleotides and thus diverted a large portion of its nitrogen to ammonia production, a potentially important result for pH regulation in its acidic habitat. Genome-scale extreme pathways elucidate emergent system-wide properties. Extreme pathway analysis is emerging as a potentially important method to analyze the link between the metabolic genotype and its phenotypes. IS - 5 JF - Genome Research EP - 769 TI - Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis VL - 12 SP - 760 KW - analysis KW - cysteine KW - extreme KW - genome-scale KW - helicobacter KW - metabolic KW - network KW - pathway KW - properties KW - pylori KW - redundancy KW - systems AU - Price, Nathan AU - Papin, Jason AU - Palsson, Bernhard PY - 2002/05/01/ UR - http://dx.doi.org/10.1101/gr.218002 ER -