SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box Export

@article{citeulike:2799793, abstract = {We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p, cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required for ubiquitin-mediated proteolysis of Cln2p, Clb5p, and the Cdk inhibitor Sic1p, and provides a link between these molecules and the proteolysis machinery. A large number of proteins contain the F-box motif and are thereby implicated in the ubiquitin pathway. Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle.}, author = {Bai, Chang and Sen, Partha and Hofmann, Kay and Ma, Lei and Goebl, Mark and Harper, Wade J. and Elledge, Stephen J.}, citeulike-article-id = {2799793}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0092-8674(00)80098-7}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WSN-4195BWM-D/1/f40df8dfb45bcfd79e34a7eeb2ed8147}, day = {26}, doi = {10.1016/S0092-8674(00)80098-7}, journal = {Cell}, keywords = {cdc4, cell, cycle, regulation, sic1}, month = {July}, number = {2}, pages = {263--274}, posted-at = {2008-05-14 20:08:03}, priority = {2}, title = {SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box}, url = {http://dx.doi.org/10.1016/S0092-8674(00)80098-7}, volume = {86}, year = {1996} }

TY - JOUR ID - citeulike:2799793 L3 - citeulike-article-id:2799793 N2 - We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p, cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required for ubiquitin-mediated proteolysis of Cln2p, Clb5p, and the Cdk inhibitor Sic1p, and provides a link between these molecules and the proteolysis machinery. A large number of proteins contain the F-box motif and are thereby implicated in the ubiquitin pathway. Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle. IS - 2 JF - Cell EP - 274 TI - SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box VL - 86 SP - 263 KW - cdc4 KW - cell KW - cycle KW - regulation KW - sic1 AU - Bai, Chang AU - Sen, Partha AU - Hofmann, Kay AU - Ma, Lei AU - Goebl, Mark AU - Harper, Wade AU - Elledge, Stephen PY - 1996/07/26/ UR - http://dx.doi.org/10.1016/S0092-8674(00)80098-7 ER -