What is the function of centrioles? Export

@article{citeulike:3380108, abstract = {The function of centrioles has been controversial and remains incompletely resolved. This is because centrioles, in and of themselves, do not directly perform any physiological activity. Instead, their role is only to act as a jig or breadboard onto which other functional structures can be built. Centrioles are primarily involved in forming two structures - centrosomes and cilia. Centrioles bias the position of spindle pole formation, but because spindle poles can self-organize, the function of the centriole in mitosis is not obligatory. Consequently, lack of centrioles does not generally prevent mitosis, although recent experiments suggest acentriolar spindles have reduced fidelity of chromosome segregation. In contrast, centrioles are absolutely required for the assembly of cilia, including primary cilia that act as cellular antennae. Consistent with this requirement, it is now becoming clear that many ciliary diseases, including nephronophthisis, Bardet-Biedl syndrome, Meckel Syndrome, and Oral-Facial-Digital syndrome, are caused by defects in centriole-associated proteins. J. Cell. Biochem. 100: 916-922, 2007. {\copyright} 2006 Wiley-Liss, Inc.}, address = {Department of Biochemistry and Biophysics, University of California, San Francisco, California}, author = {Marshall, Wallace F.}, citeulike-article-id = {3380108}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jcb.21117}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17115414}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17115414}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/113453994/ABSTRACT}, doi = {10.1002/jcb.21117}, journal = {Journal of Cellular Biochemistry}, keywords = {centriole, function, spindle}, number = {4}, pages = {916--922}, posted-at = {2008-10-06 15:58:54}, priority = {2}, title = {What is the function of centrioles?}, url = {http://dx.doi.org/10.1002/jcb.21117}, volume = {100}, year = {2007} }

TY - JOUR ID - citeulike:3380108 L3 - citeulike-article-id:3380108 N2 - The function of centrioles has been controversial and remains incompletely resolved. This is because centrioles, in and of themselves, do not directly perform any physiological activity. Instead, their role is only to act as a jig or breadboard onto which other functional structures can be built. Centrioles are primarily involved in forming two structures - centrosomes and cilia. Centrioles bias the position of spindle pole formation, but because spindle poles can self-organize, the function of the centriole in mitosis is not obligatory. Consequently, lack of centrioles does not generally prevent mitosis, although recent experiments suggest acentriolar spindles have reduced fidelity of chromosome segregation. In contrast, centrioles are absolutely required for the assembly of cilia, including primary cilia that act as cellular antennae. Consistent with this requirement, it is now becoming clear that many ciliary diseases, including nephronophthisis, Bardet-Biedl syndrome, Meckel Syndrome, and Oral-Facial-Digital syndrome, are caused by defects in centriole-associated proteins. J. Cell. Biochem. 100: 916-922, 2007. © 2006 Wiley-Liss, Inc. IS - 4 JF - Journal of Cellular Biochemistry AD - Department of Biochemistry and Biophysics, University of California, San Francisco, California EP - 922 TI - What is the function of centrioles? VL - 100 SP - 916 KW - centriole KW - function KW - spindle AU - Marshall, Wallace PY - 2007/// UR - http://dx.doi.org/10.1002/jcb.21117 ER -