Physical Properties Determining Self-Organization of Motors and Microtubules Export

@article{Surrey2001, abstract = {In eukaryotic cells, microtubules and their associated motor proteins can be organized into various large-scale patterns. Using a simplified experimental system combined with computer simulations, we examined how the concentrations and kinetic parameters of the motors contribute to their collective behavior. We observed self-organization of generic steady-state structures such as asters, vortices, and a network of interconnected poles. We identified parameter combinations that determine the generation of each of these structures. In general, this approach may become useful for correlating the morphogenetic phenomena taking place in a biological system with the biophysical characteristics of its constituents.}, author = {Surrey, Thomas and Nedelec, Francois and Leibler, Stanislas and Karsenti, Eric}, citeulike-article-id = {466981}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1059758}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/292/5519/1167}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11349149}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11349149}, day = {11}, doi = {10.1126/science.1059758}, journal = {Science}, keywords = {microtubules, motors}, month = {May}, number = {5519}, pages = {1167--1171}, posted-at = {2007-07-20 10:07:04}, priority = {5}, title = {Physical Properties Determining Self-Organization of Motors and Microtubules}, url = {http://dx.doi.org/10.1126/science.1059758}, volume = {292}, year = {2001} }

TY - JOUR ID - Surrey2001 L3 - citeulike-article-id:466981 N2 - In eukaryotic cells, microtubules and their associated motor proteins can be organized into various large-scale patterns. Using a simplified experimental system combined with computer simulations, we examined how the concentrations and kinetic parameters of the motors contribute to their collective behavior. We observed self-organization of generic steady-state structures such as asters, vortices, and a network of interconnected poles. We identified parameter combinations that determine the generation of each of these structures. In general, this approach may become useful for correlating the morphogenetic phenomena taking place in a biological system with the biophysical characteristics of its constituents. IS - 5519 JF - Science EP - 1171 TI - Physical Properties Determining Self-Organization of Motors and Microtubules VL - 292 SP - 1167 KW - microtubules KW - motors AU - Surrey, Thomas AU - Nedelec, Francois AU - Leibler, Stanislas AU - Karsenti, Eric PY - 2001/05/11/ UR - http://dx.doi.org/10.1126/science.1059758 ER -