Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. Export

@article{citeulike:2800685, abstract = {We investigated the signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in murine macrophages in response to 15-deoxy-delta 12,14-prostaglandin J2 (15dPGJ2). 15dPGJ2 caused dose- and time-dependent activation of Rac1, followed by a transient increase in reactive oxygen species (ROS) via NADPH oxidase, which leads to downstream activation of p38 kinase. Inhibition of 15dPGJ2-dependent HO-1 expression significantly attenuated suppression by 15dPGJ2 of LPS-induced iNOS expression and subsequent production of nitric oxide (NO). Our findings strongly suggest that 15dPGJ2 exerts its anti-inflammatory activity through the Rac1-NADPH oxidase-ROS-p38 signaling to the up-regulation of HO-1 in an in vitro inflammation model.}, address = {Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 200-701, Republic of Korea.}, author = {Hong, H. Y. and Jeon, W. K. and Kim, B. C.}, citeulike-article-id = {2800685}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.febslet.2008.02.012}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18291107}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18291107}, day = {19}, doi = {10.1016/j.febslet.2008.02.012}, issn = {0014-5793}, journal = {FEBS letters}, keywords = {inflammation, macrophage, ppargamma, signal}, month = {March}, number = {6}, pages = {861--868}, posted-at = {2008-05-15 05:47:01}, priority = {2}, title = {Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages.}, url = {http://dx.doi.org/10.1016/j.febslet.2008.02.012}, volume = {582}, year = {2008} }

TY - JOUR ID - citeulike:2800685 L3 - citeulike-article-id:2800685 N2 - We investigated the signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in murine macrophages in response to 15-deoxy-delta 12,14-prostaglandin J2 (15dPGJ2). 15dPGJ2 caused dose- and time-dependent activation of Rac1, followed by a transient increase in reactive oxygen species (ROS) via NADPH oxidase, which leads to downstream activation of p38 kinase. Inhibition of 15dPGJ2-dependent HO-1 expression significantly attenuated suppression by 15dPGJ2 of LPS-induced iNOS expression and subsequent production of nitric oxide (NO). Our findings strongly suggest that 15dPGJ2 exerts its anti-inflammatory activity through the Rac1-NADPH oxidase-ROS-p38 signaling to the up-regulation of HO-1 in an in vitro inflammation model. IS - 6 JF - FEBS letters SN - 0014-5793 AD - Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 200-701, Republic of Korea. EP - 868 TI - Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. VL - 582 SP - 861 KW - inflammation KW - macrophage KW - ppargamma KW - signal AU - Hong, HY AU - Jeon, WK AU - Kim, BC PY - 2008/03/19/ UR - http://dx.doi.org/10.1016/j.febslet.2008.02.012 ER -