5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen isolated from Angelica dahurica inhibits cyclooxygenase-2 and 5-Lipoxygenase in mouse bone marrow-derived mast cells. Export

@article{citeulike:2811409, abstract = {5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen (MP) is a medicinal herbal product isolated from Angelica dahurica that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (IC(50), 23.5 muM). Western blotting with specific anti-COX-2 antibodies showed that the decrease in PGD(2) production was accompanied by a decrease in COX-2 protein levels. In addition, this compound consistently inhibited the production of leukotriene C(4) in a dose dependent manner, (IC(50), 2.5 muM). These results demonstrate that MP inhibits both cyclooxygenase-2 and 5-lipoxygenase activity. Furthermore, this compound also inhibited the degranulation reaction (IC(50), 4.1 muM). Therefore, this compound might provide a basis for novel anti-inflammatory drug development.}, address = {College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.}, author = {Hua, J. M. and Moon, T. C. and Hong, T. G. and Park, K. M. and Son, J. K. and Chang, H. W.}, citeulike-article-id = {2811409}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s12272-001-1202-9}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18481018}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18481018}, doi = {10.1007/s12272-001-1202-9}, issn = {0253-6269}, journal = {Archives of pharmacal research}, keywords = {5-lox, cox-2, mast}, month = {May}, number = {5}, pages = {617--621}, posted-at = {2008-05-19 02:29:41}, priority = {2}, title = {5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen isolated from Angelica dahurica inhibits cyclooxygenase-2 and 5-Lipoxygenase in mouse bone marrow-derived mast cells.}, url = {http://dx.doi.org/10.1007/s12272-001-1202-9}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2811409 L3 - citeulike-article-id:2811409 N2 - 5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen (MP) is a medicinal herbal product isolated from Angelica dahurica that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (IC(50), 23.5 muM). Western blotting with specific anti-COX-2 antibodies showed that the decrease in PGD(2) production was accompanied by a decrease in COX-2 protein levels. In addition, this compound consistently inhibited the production of leukotriene C(4) in a dose dependent manner, (IC(50), 2.5 muM). These results demonstrate that MP inhibits both cyclooxygenase-2 and 5-lipoxygenase activity. Furthermore, this compound also inhibited the degranulation reaction (IC(50), 4.1 muM). Therefore, this compound might provide a basis for novel anti-inflammatory drug development. IS - 5 JF - Archives of pharmacal research SN - 0253-6269 AD - College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea. EP - 621 TI - 5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen isolated from Angelica dahurica inhibits cyclooxygenase-2 and 5-Lipoxygenase in mouse bone marrow-derived mast cells. VL - 31 SP - 617 KW - 5-lox KW - cox-2 KW - mast AU - Hua, JM AU - Moon, TC AU - Hong, TG AU - Park, KM AU - Son, JK AU - Chang, HW PY - 2008/05// UR - http://dx.doi.org/10.1007/s12272-001-1202-9 ER -