Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. Export

@article{citeulike:2831035, abstract = {In inflammatory and oxidative liver injury, virus proteins and reactive oxygen species are involved in the regulation of proinflammatory cytokine production by macrophages. This study investigated the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stress-stimulated production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, macrophage inflammatory protein (MIP)-2, and macrophage chemotactic protein (MCP)-1 by peritoneal macrophages isolated from male and female mice. E2 inhibited the cytokine production of TNF-alpha, IL-1beta, MIP-2, and MCP-1 by the unstimulated macrophages from males and females, which was then further stimulated by progesterone. The exposure to hydrogen peroxide in the macrophages from both sexes induced the production of cytokine. The hydrogen peroxide-stimulated cytokine production was suppressed by E2 and enhanced by progesterone. The sex hormone effects on the unstimulated and stimulated macrophages were blocked by their receptor antagonists and showed no significant difference between male and female subjects. These findings suggest that E2 may play a favorable role in the course of persistent liver injury, by inhibiting proinflammatory cytokine production, which, in addition, progesterone may counteract the favorable E2 effects through their receptors.}, address = {Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School, Tokushima, Japan.}, author = {Huang, H. and He, J. and Yuan, Y. and Aoyagi, E. and Takenaka, H. and Itagaki, T. and Sannomiya, K. and Tamaki, K. and Harada, N. and Shono, M. and Shimizu, I. and Takayama, T.}, citeulike-article-id = {2831035}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18319556}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18319556}, issn = {1343-1420}, journal = {The journal of medical investigation : JMI}, keywords = {macrophage, nuclear\_receptors}, month = {February}, number = {1-2}, pages = {133--141}, posted-at = {2008-05-25 18:12:17}, priority = {2}, title = {Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18319556}, volume = {55}, year = {2008} }

TY - JOUR ID - citeulike:2831035 L3 - citeulike-article-id:2831035 N2 - In inflammatory and oxidative liver injury, virus proteins and reactive oxygen species are involved in the regulation of proinflammatory cytokine production by macrophages. This study investigated the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stress-stimulated production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, macrophage inflammatory protein (MIP)-2, and macrophage chemotactic protein (MCP)-1 by peritoneal macrophages isolated from male and female mice. E2 inhibited the cytokine production of TNF-alpha, IL-1beta, MIP-2, and MCP-1 by the unstimulated macrophages from males and females, which was then further stimulated by progesterone. The exposure to hydrogen peroxide in the macrophages from both sexes induced the production of cytokine. The hydrogen peroxide-stimulated cytokine production was suppressed by E2 and enhanced by progesterone. The sex hormone effects on the unstimulated and stimulated macrophages were blocked by their receptor antagonists and showed no significant difference between male and female subjects. These findings suggest that E2 may play a favorable role in the course of persistent liver injury, by inhibiting proinflammatory cytokine production, which, in addition, progesterone may counteract the favorable E2 effects through their receptors. IS - 1-2 JF - The journal of medical investigation : JMI SN - 1343-1420 AD - Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School, Tokushima, Japan. EP - 141 TI - Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. VL - 55 SP - 133 KW - macrophage KW - nuclear_receptors AU - Huang, H AU - He, J AU - Yuan, Y AU - Aoyagi, E AU - Takenaka, H AU - Itagaki, T AU - Sannomiya, K AU - Tamaki, K AU - Harada, N AU - Shono, M AU - Shimizu, I AU - Takayama, T PY - 2008/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/18319556 ER -