Does COX2-dependent PGE2 play a role in neuropathic pain? Export

@article{citeulike:3177622, abstract = {Neuropathic pain (NeP) is a common chronic pain state with unmet medical needs. Due to poorly defined underlying mechanisms, current therapies for NeP are far from satisfactory. Mounting evidence suggests that long-term plasticity in pain signaling pathways underpins the pathogenesis of NeP. Inflammatory responses in injured nerves have been recognized as important events initially sensitizing nociceptive neurons and subsequently inducing long-term plasticity in the dorsal root ganglion. Inflammatory cells such as invading macrophages and Schwann cells produce a wide array of inflammatory mediators. Cyclooxygenase 2-dependent prostaglandin E2 (COX2/PGE2) is one of the important mediator abundantly produced in injured nerves and involved in the genesis of NeP. In this mini-review, we highlight possible novel mechanisms underlying the role of COX2/PGE2 in injured nerves in the genesis of NeP. Long lasting COX2/PGE2 in injured nerves may induce chronic effects on nociceptors to facilitate the synthesis of pain-related molecules by stimulating 'en passant' injured or spared axons. COX2/PGE2 may also induce chronic effects on local inflammatory cells in injured nerves to facilitate the synthesis of inflammatory mediators via autocrine and paracrine pathways. COX2/PGE2 in injured nerves and downstream PGE2 EP receptor signaling should be considered as therapeutic targets to more effectively treat chronic NeP.}, address = {The Douglas Mental Health University Institute, Montr\'{e}al, Quebec, Canada H4H 1R3. weiya.ma@douglas.mcgill.ca <weiya.ma@douglas.mcgill.ca>}, author = {Ma, W. and Quirion, R.}, citeulike-article-id = {3177622}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neulet.2008.02.072}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18434017}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18434017}, day = {6}, doi = {10.1016/j.neulet.2008.02.072}, issn = {0304-3940}, journal = {Neuroscience letters}, keywords = {cox-2, pge2}, month = {June}, number = {3}, pages = {165--169}, posted-at = {2008-09-01 08:30:03}, priority = {2}, title = {Does COX2-dependent PGE2 play a role in neuropathic pain?}, url = {http://dx.doi.org/10.1016/j.neulet.2008.02.072}, volume = {437}, year = {2008} }

TY - JOUR ID - citeulike:3177622 L3 - citeulike-article-id:3177622 N2 - Neuropathic pain (NeP) is a common chronic pain state with unmet medical needs. Due to poorly defined underlying mechanisms, current therapies for NeP are far from satisfactory. Mounting evidence suggests that long-term plasticity in pain signaling pathways underpins the pathogenesis of NeP. Inflammatory responses in injured nerves have been recognized as important events initially sensitizing nociceptive neurons and subsequently inducing long-term plasticity in the dorsal root ganglion. Inflammatory cells such as invading macrophages and Schwann cells produce a wide array of inflammatory mediators. Cyclooxygenase 2-dependent prostaglandin E2 (COX2/PGE2) is one of the important mediator abundantly produced in injured nerves and involved in the genesis of NeP. In this mini-review, we highlight possible novel mechanisms underlying the role of COX2/PGE2 in injured nerves in the genesis of NeP. Long lasting COX2/PGE2 in injured nerves may induce chronic effects on nociceptors to facilitate the synthesis of pain-related molecules by stimulating 'en passant' injured or spared axons. COX2/PGE2 may also induce chronic effects on local inflammatory cells in injured nerves to facilitate the synthesis of inflammatory mediators via autocrine and paracrine pathways. COX2/PGE2 in injured nerves and downstream PGE2 EP receptor signaling should be considered as therapeutic targets to more effectively treat chronic NeP. IS - 3 JF - Neuroscience letters SN - 0304-3940 AD - The Douglas Mental Health University Institute, Montréal, Quebec, Canada H4H 1R3. weiya.ma@douglas.mcgill.ca <weiya.ma@douglas.mcgill.ca> EP - 169 TI - Does COX2-dependent PGE2 play a role in neuropathic pain? VL - 437 SP - 165 KW - cox-2 KW - pge2 AU - Ma, W AU - Quirion, R PY - 2008/06/06/ UR - http://dx.doi.org/10.1016/j.neulet.2008.02.072 ER -