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The Akt Inhibitor MK2206 Synergizes, but Perifosine Antagonizes, the BRAFV600E Inhibitor PLX4032 and the MEK1/2 Inhibitor AZD6244 in the Inhibition of Thyroid Cancer Cells
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Journal of Clinical Endocrinology & Metabolism, Vol. 97, No. 2. (01 February 2012), pp. E173-E182, doi:10.1210/jc.2011-1054 Key: citeulike:11867736
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Purpose: The purpose of the study was to explore optimal combinations of currently actively developed drugs for dually targeting the Ras → Raf → MAPK kinase (MEK) → MAPK/ERK (MAPK) and the phosphatidylinositol 3-kinase/Akt pathways as effective treatments for thyroid cancer.
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