Elevated expression levels of <I>NCOA3</I>, <I>TOP1</I>, and <I>TFAP2C</I> in breast tumors as predictors of poor prognosis Export

@article{citeulike:3094815, abstract = {Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in primary breast tumors. The aim of the current study was to identify specific genes in the 20q amplicon that were likely to have clinical significance.The authors examined 38 primary breast tumors by using a quantitative real-time reverse transcription-polymerase chain reaction assay to determine expression levels of 18 potential targets for amplification events involving 20q. Potential correlations between elevated expression of the genes in question and clinicopathologic parameters or clinical outcomes were analyzed.Elevated expression of NABC1 was significantly associated with positive estrogen (P \&lt; 0.001) and progesterone (P = 0.027) receptors in breast tumors, and high expression of PTK6 was significantly correlated with positive estrogen receptor status (P = 0.022) and postmenopausal status (P = 0.008). Patients whose tumors showed elevated expression of NCOA3 (AIB1) had significantly shorter disease-free (P = 0.017) and overall (P = 0.0021) survival times after surgery than did other patients with breast tumors. Reduced disease-free survival, but not reduced overall survival, was associated with high expression of TOP1 (P = 0.035) and TFAP2C (P = 0.035).TOP1, TFAP2C, and (particularly) NCOA3 may be prognostic indicators for patients with breast tumors. Cancer 2003;98:18-23. {\copyright} 2003 American Cancer Society.DOI 10.1002/cncr.11482}, address = {Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Kuwaguchi, Japan; Kyoto First Red Cross Hospital, Kyoto, Japan}, author = {Zhao, Chen and Yasui, Kohichiroh and Lee, Chol J. and Kurioka, Hideaki and Hosokawa, Youhei and Oka, Takahiro and Inazawa, Johji}, citeulike-article-id = {3094815}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/cncr.11482}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/104532864/ABSTRACT}, doi = {10.1002/cncr.11482}, journal = {Cancer}, keywords = {20q, breast, ncoa3, tfap2c, top1}, number = {1}, pages = {18--23}, posted-at = {2008-08-07 10:10:16}, priority = {2}, title = {Elevated expression levels of <I>NCOA3</I>, <I>TOP1</I>, and <I>TFAP2C</I> in breast tumors as predictors of poor prognosis}, url = {http://dx.doi.org/10.1002/cncr.11482}, volume = {98}, year = {2003} }

TY - JOUR ID - citeulike:3094815 L3 - citeulike-article-id:3094815 N2 - Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in primary breast tumors. The aim of the current study was to identify specific genes in the 20q amplicon that were likely to have clinical significance.The authors examined 38 primary breast tumors by using a quantitative real-time reverse transcription-polymerase chain reaction assay to determine expression levels of 18 potential targets for amplification events involving 20q. Potential correlations between elevated expression of the genes in question and clinicopathologic parameters or clinical outcomes were analyzed.Elevated expression of NABC1 was significantly associated with positive estrogen (P &lt; 0.001) and progesterone (P = 0.027) receptors in breast tumors, and high expression of PTK6 was significantly correlated with positive estrogen receptor status (P = 0.022) and postmenopausal status (P = 0.008). Patients whose tumors showed elevated expression of NCOA3 (AIB1) had significantly shorter disease-free (P = 0.017) and overall (P = 0.0021) survival times after surgery than did other patients with breast tumors. Reduced disease-free survival, but not reduced overall survival, was associated with high expression of TOP1 (P = 0.035) and TFAP2C (P = 0.035).TOP1, TFAP2C, and (particularly) NCOA3 may be prognostic indicators for patients with breast tumors. Cancer 2003;98:18-23. © 2003 American Cancer Society.DOI 10.1002/cncr.11482 IS - 1 JF - Cancer AD - Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Kuwaguchi, Japan; Kyoto First Red Cross Hospital, Kyoto, Japan EP - 23 TI - Elevated expression levels of <I>NCOA3</I>, <I>TOP1</I>, and <I>TFAP2C</I> in breast tumors as predictors of poor prognosis VL - 98 SP - 18 KW - 20q KW - breast KW - ncoa3 KW - tfap2c KW - top1 AU - Zhao, Chen AU - Yasui, Kohichiroh AU - Lee, Chol AU - Kurioka, Hideaki AU - Hosokawa, Youhei AU - Oka, Takahiro AU - Inazawa, Johji PY - 2003/// UR - http://dx.doi.org/10.1002/cncr.11482 ER -