Concerted Activation of ETS Protein ER81 by p160 Coactivators, the Acetyltransferase p300 and the Receptor Tyrosine Kinase HER2/Neu Export

@article{citeulike:3094837, abstract = {Activator of thyroid and retinoic acid receptor (ACTR) is overexpressed in [\~{}]60\% of primary human breast tumors and belongs to the p160 steroid receptor coactivator family. In this study, we identified a novel interaction partner of ACTR, the ETS transcription factor ER81 that is also heavily implicated in mammary tumor formation. ACTR and related p160 family members (steroid receptor coactivator-1 and glucocorticoid receptor-interacting protein-1 (GRIP-1)) augment ER81-mediated transcription. Although ACTR and GRIP-1 can acetylate ER81, this posttranslational modification of ER81 is not required for its stimulation by ACTR or GRIP-1. In addition, ACTR collaborates with the p300 coactivator, a joint interaction partner of ACTR and ER81, to stimulate ER81 function and the ability of p300 to acetylate ER81 is indispensable for this collaboration. Furthermore, the receptor tyrosine kinase HER2/Neu, an oncoprotein particularly found overexpressed in breast tumors, cooperates with both ACTR and p300 to stimulate ER81-mediated transcription. Thus, oncogenic HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes. 10.1074/jbc.M400036200}, author = {Goel, Apollina and Janknecht, Ralf}, citeulike-article-id = {3094837}, citeulike-linkout-0 = {http://dx.doi.org/10.1074/jbc.M400036200}, citeulike-linkout-1 = {http://www.jbc.org/cgi/content/abstract/279/15/14909}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/14747462}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=14747462}, day = {9}, doi = {10.1074/jbc.M400036200}, journal = {J. Biol. Chem.}, keywords = {20q, actr, ets, ncoa3}, month = {April}, number = {15}, pages = {14909--14916}, posted-at = {2008-08-07 10:31:27}, priority = {2}, title = {Concerted Activation of ETS Protein ER81 by p160 Coactivators, the Acetyltransferase p300 and the Receptor Tyrosine Kinase HER2/Neu}, url = {http://dx.doi.org/10.1074/jbc.M400036200}, volume = {279}, year = {2004} }

TY - JOUR ID - citeulike:3094837 L3 - citeulike-article-id:3094837 N2 - Activator of thyroid and retinoic acid receptor (ACTR) is overexpressed in [~]60% of primary human breast tumors and belongs to the p160 steroid receptor coactivator family. In this study, we identified a novel interaction partner of ACTR, the ETS transcription factor ER81 that is also heavily implicated in mammary tumor formation. ACTR and related p160 family members (steroid receptor coactivator-1 and glucocorticoid receptor-interacting protein-1 (GRIP-1)) augment ER81-mediated transcription. Although ACTR and GRIP-1 can acetylate ER81, this posttranslational modification of ER81 is not required for its stimulation by ACTR or GRIP-1. In addition, ACTR collaborates with the p300 coactivator, a joint interaction partner of ACTR and ER81, to stimulate ER81 function and the ability of p300 to acetylate ER81 is indispensable for this collaboration. Furthermore, the receptor tyrosine kinase HER2/Neu, an oncoprotein particularly found overexpressed in breast tumors, cooperates with both ACTR and p300 to stimulate ER81-mediated transcription. Thus, oncogenic HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes. 10.1074/jbc.M400036200 IS - 15 JF - J. Biol. Chem. EP - 14916 TI - Concerted Activation of ETS Protein ER81 by p160 Coactivators, the Acetyltransferase p300 and the Receptor Tyrosine Kinase HER2/Neu VL - 279 SP - 14909 KW - 20q KW - actr KW - ets KW - ncoa3 AU - Goel, Apollina AU - Janknecht, Ralf PY - 2004/04/09/ UR - http://dx.doi.org/10.1074/jbc.M400036200 ER -