Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells Export

@article{citeulike:3467789, abstract = {Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells. 10.1126/science.1160058}, author = {Williams, Bret R. and Prabhu, Vineet R. and Hunter, Karen E. and Glazier, Christina M. and Whittaker, Charles A. and Housman, David E. and Amon, Angelika}, booktitle = {Science}, citeulike-article-id = {3467789}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1160058}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/322/5902/703}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18974345}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18974345}, day = {31}, doi = {10.1126/science.1160058}, journal = {Science}, keywords = {20q}, month = {October}, number = {5902}, pages = {703--709}, posted-at = {2008-11-09 09:24:59}, priority = {0}, title = {Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells}, url = {http://dx.doi.org/10.1126/science.1160058}, volume = {322}, year = {2008} }

TY - JOUR ID - citeulike:3467789 L3 - citeulike-article-id:3467789 N2 - Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells. 10.1126/science.1160058 IS - 5902 JF - Science EP - 709 TI - Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells VL - 322 T2 - Science SP - 703 KW - 20q AU - Williams, Bret AU - Prabhu, Vineet AU - Hunter, Karen AU - Glazier, Christina AU - Whittaker, Charles AU - Housman, David AU - Amon, Angelika PY - 2008/10/31/ UR - http://dx.doi.org/10.1126/science.1160058 ER -