Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results Export

@article{citeulike:1052669, abstract = {PurposeThe objective of this study was to assess changes in the water apparent diffusion coefficient (ADC) and in pharmacokinetic parameters obtained from the fast-exchange regime (FXR) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during neoadjuvant chemotherapy in breast cancer.Materials and MethodsEleven patients with locally advanced breast cancer underwent MRI examination prior to and after chemotherapy but prior to surgery. A 1.5-T scanner was used to obtain T1, ADC and DCE-MRI data. DCE-MRI data were analyzed by the FXR model returning estimates of Ktrans (volume transfer constant), ve (extravascular extracellular volume fraction) and [tau]i (average intracellular water lifetime). Histogram and correlation analyses assessed parameter changes post-treatment.ResultsSignificant (PP[tau]i, although there was qualitative reduction in [tau]i values post-treatment. In particular, there was reduction (PKtrans values in the range 0.2-0.5 min-1 and a decrease (P-3 to 1.35x10-3 mm2/s. ADC and ve were negatively correlated (r=-.60, PT1, ve, [tau]i and ADC) correlated with a multivariable linear regression model.ConclusionThe analysis presented here is sensitive to longitudinal changes in breast tumor status; Ktrans and ADC are most sensitive to these changes. Relationships between parameters provide information on water distribution and geometry in the tumor environment.}, author = {Yankeelov, Thomas E. and Lepage, Martin and Chakravarthy, Anuradha and Broome, Elizabeth E. and Niermann, Kenneth J. and Kelley, Mark C. and Meszoely, Ingrid and Mayer, Ingrid A. and Herman, Cheryl R. and Mcmanus, Kevin}, citeulike-article-id = {1052669}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mri.2006.09.006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17222711}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17222711}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T9D-4MD4670-1/2/2c61f565910ef298105388fef144292a}, doi = {10.1016/j.mri.2006.09.006}, journal = {Magnetic Resonance Imaging}, keywords = {breast, dce, diffusion, mri, nmr, response, treatment}, month = {January}, number = {1}, pages = {1--13}, posted-at = {2008-09-12 08:51:28}, priority = {5}, title = {Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results}, url = {http://dx.doi.org/10.1016/j.mri.2006.09.006}, volume = {25}, year = {2007} }

TY - JOUR ID - citeulike:1052669 L3 - citeulike-article-id:1052669 N2 - PurposeThe objective of this study was to assess changes in the water apparent diffusion coefficient (ADC) and in pharmacokinetic parameters obtained from the fast-exchange regime (FXR) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during neoadjuvant chemotherapy in breast cancer.Materials and MethodsEleven patients with locally advanced breast cancer underwent MRI examination prior to and after chemotherapy but prior to surgery. A 1.5-T scanner was used to obtain T1, ADC and DCE-MRI data. DCE-MRI data were analyzed by the FXR model returning estimates of Ktrans (volume transfer constant), ve (extravascular extracellular volume fraction) and [tau]i (average intracellular water lifetime). Histogram and correlation analyses assessed parameter changes post-treatment.ResultsSignificant (PP[tau]i, although there was qualitative reduction in [tau]i values post-treatment. In particular, there was reduction (PKtrans values in the range 0.2-0.5 min-1 and a decrease (P-3 to 1.35x10-3 mm2/s. ADC and ve were negatively correlated (r=-.60, PT1, ve, [tau]i and ADC) correlated with a multivariable linear regression model.ConclusionThe analysis presented here is sensitive to longitudinal changes in breast tumor status; Ktrans and ADC are most sensitive to these changes. Relationships between parameters provide information on water distribution and geometry in the tumor environment. IS - 1 JF - Magnetic Resonance Imaging EP - 13 TI - Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results VL - 25 SP - 1 KW - breast KW - dce KW - diffusion KW - mri KW - nmr KW - response KW - treatment AU - Yankeelov, Thomas AU - Lepage, Martin AU - Chakravarthy, Anuradha AU - Broome, Elizabeth AU - Niermann, Kenneth AU - Kelley, Mark AU - Meszoely, Ingrid AU - Mayer, Ingrid AU - Herman, Cheryl AU - Mcmanus, Kevin PY - 2007/01// UR - http://dx.doi.org/10.1016/j.mri.2006.09.006 ER -