Three-dimensional dosimetry using polymer gel and magnetic resonance imaging applied to the verification of conformal radiation therapy in head-and-neck cancer Export

@article{citeulike:3208251, abstract = {Background and purpose: It was our aim to investigate NMR-based BANG gel dosimetry as a three-dimensional dosimetry technique in conformal radiotherapy. Materials and methods: The BANG gel consisting of gelatin, water and co-monomers was first validated in a cylindrical glass flask for a single standard beam. Next, the gel contained in a human neck-shaped cast was used to verify a treatment plan for the conformal irradiation of a concave tumour in the lower neck. Magnetic resonance relaxation rate images were acquired and, based on an appropriate calibration of the gel, converted to absorbed dose distributions. The resulting maps were compared with dose distributions measured using radiographic film. Results: The gel-measured dose profiles of standard beams agreed within 3\% (root mean square difference) with the profiles measured with high spatial resolution by a diamond detector. For the multi-beam conformal treatment, the difference map between gel-measured and film-measured dose distributions revealed a noise component and a more systematic deviation including structural or space-coherent patterns. The mean absolute value of the difference amounted to 8\%. A number of possible causes for this deviation are designated. Conclusions: Polymer gel dosimetry in combination with magnetic resonance imaging is a promising method for dosimetric verification of conformal radiotherapy.}, author = {De Deene, Y. and De Wagter, C. and Van Duyse, B. and Derycke, S. and De Neve, W. and Achten, E.}, citeulike-article-id = {3208251}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0167-8140(98)00087-5}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6TBY-3V7RVX9-6/2/9dd5134bd88b51603edc20640c129011}, doi = {10.1016/S0167-8140(98)00087-5}, journal = {Radiotherapy and Oncology}, keywords = {applications, dosimetry, gel}, month = {September}, number = {3}, pages = {283--291}, posted-at = {2008-09-09 09:00:45}, priority = {0}, title = {Three-dimensional dosimetry using polymer gel and magnetic resonance imaging applied to the verification of conformal radiation therapy in head-and-neck cancer}, url = {http://dx.doi.org/10.1016/S0167-8140(98)00087-5}, volume = {48}, year = {1998} }

TY - JOUR ID - citeulike:3208251 L3 - citeulike-article-id:3208251 N2 - Background and purpose: It was our aim to investigate NMR-based BANG gel dosimetry as a three-dimensional dosimetry technique in conformal radiotherapy. Materials and methods: The BANG gel consisting of gelatin, water and co-monomers was first validated in a cylindrical glass flask for a single standard beam. Next, the gel contained in a human neck-shaped cast was used to verify a treatment plan for the conformal irradiation of a concave tumour in the lower neck. Magnetic resonance relaxation rate images were acquired and, based on an appropriate calibration of the gel, converted to absorbed dose distributions. The resulting maps were compared with dose distributions measured using radiographic film. Results: The gel-measured dose profiles of standard beams agreed within 3% (root mean square difference) with the profiles measured with high spatial resolution by a diamond detector. For the multi-beam conformal treatment, the difference map between gel-measured and film-measured dose distributions revealed a noise component and a more systematic deviation including structural or space-coherent patterns. The mean absolute value of the difference amounted to 8%. A number of possible causes for this deviation are designated. Conclusions: Polymer gel dosimetry in combination with magnetic resonance imaging is a promising method for dosimetric verification of conformal radiotherapy. IS - 3 JF - Radiotherapy and Oncology EP - 291 TI - Three-dimensional dosimetry using polymer gel and magnetic resonance imaging applied to the verification of conformal radiation therapy in head-and-neck cancer VL - 48 SP - 283 KW - applications KW - dosimetry KW - gel AU - De Deene, Y AU - De Wagter, C AU - Van Duyse, B AU - Derycke, S AU - De Neve, W AU - Achten, E PY - 1998/09// UR - http://dx.doi.org/10.1016/S0167-8140(98)00087-5 ER -