Inulin as a Carrier for Contrast Agents in Magnetic Resonance Imaging Export

@article{citeulike:3226081, abstract = {Magnetic resonance angiography (MRA) has put forth an impetus for the development of macromolecular GdIII complexes that have a prolonged lifetime in the vascular system. Herein, we report the synthesis and GdIII complexation of a new sugar conjugate based on inulin and the DO3A ligand (DO3A=1,4,7,10-tetraazacyclododecan-1,4,7-triacetic acid). Two API-DO3ASQ conjugates (API=O-(aminopropyl)inulin, SQ=squaric acid=3,4-dihydroxy-3-cyclobutene-1,2-dione) with different degrees of substitution (ds=0.7 and ds=1.5) were prepared from API by using the diethyl ester of squaric acid as a linking agent for the DO3A chelate. The efficacies of the resulting GdIII compounds were evaluated by investigation of their water 1H longitudinal-relaxation-rate enhancements at variable field (NMRD). A dramatic increase in relaxivity was observed in the more highly substituted conjugate (ds=1.5); this prompted us to do a variable-temperature 17O study in order to further characterize the relaxation parameters involved in this system. [Gd(API-DO3ASQ)] shows promising properties for application as a contrast agent for MRI.}, address = {Laboratory of Applied Organic Chemistry and Catalysis Delft University of Technology, Julianalaan 136, 2628 BL Delft (The Netherlands) Fax: (+31) 15-278-4289; NMR Laboratory, Department of Organic Chemistry University of Mons-Hainaut, 7000 Mons (Belgium)}, author = {Daniele m and Vander elst, Luce and Robert n and van Bekkum, Herman and Joop a}, citeulike-article-id = {3226081}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/1521-3765(20010105)7:1%3C64::AID-CHEM64%3E3.0.CO;2-S}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/76506329/ABSTRACT}, doi = {10.1002/1521-3765(20010105)7:1%3C64::AID-CHEM64%3E3.0.CO;2-S}, journal = {Chemistry}, keywords = {agent, carrier, contrast, mri, nmr}, number = {1}, pages = {64--71}, posted-at = {2008-09-11 19:02:50}, priority = {1}, title = {Inulin as a Carrier for Contrast Agents in Magnetic Resonance Imaging}, url = {http://dx.doi.org/10.1002/1521-3765(20010105)7:1%3C64::AID-CHEM64%3E3.0.CO;2-S}, volume = {7}, year = {2001} }

TY - JOUR ID - citeulike:3226081 L3 - citeulike-article-id:3226081 N2 - Magnetic resonance angiography (MRA) has put forth an impetus for the development of macromolecular GdIII complexes that have a prolonged lifetime in the vascular system. Herein, we report the synthesis and GdIII complexation of a new sugar conjugate based on inulin and the DO3A ligand (DO3A=1,4,7,10-tetraazacyclododecan-1,4,7-triacetic acid). Two API-DO3ASQ conjugates (API=O-(aminopropyl)inulin, SQ=squaric acid=3,4-dihydroxy-3-cyclobutene-1,2-dione) with different degrees of substitution (ds=0.7 and ds=1.5) were prepared from API by using the diethyl ester of squaric acid as a linking agent for the DO3A chelate. The efficacies of the resulting GdIII compounds were evaluated by investigation of their water 1H longitudinal-relaxation-rate enhancements at variable field (NMRD). A dramatic increase in relaxivity was observed in the more highly substituted conjugate (ds=1.5); this prompted us to do a variable-temperature 17O study in order to further characterize the relaxation parameters involved in this system. [Gd(API-DO3ASQ)] shows promising properties for application as a contrast agent for MRI. IS - 1 JF - Chemistry AD - Laboratory of Applied Organic Chemistry and Catalysis Delft University of Technology, Julianalaan 136, 2628 BL Delft (The Netherlands) Fax: (+31) 15-278-4289; NMR Laboratory, Department of Organic Chemistry University of Mons-Hainaut, 7000 Mons (Belgium) EP - 71 TI - Inulin as a Carrier for Contrast Agents in Magnetic Resonance Imaging VL - 7 SP - 64 KW - agent KW - carrier KW - contrast KW - mri KW - nmr AU - Daniele m AU - Vander elst, Luce AU - Robert n AU - van Bekkum, Herman AU - Joop a PY - 2001/// UR - http://dx.doi.org/10.1002/1521-3765(20010105)7:1%3C64::AID-CHEM64%3E3.0.CO;2-S ER -