Quantitative proton magnetic resonance spectroscopic imaging: Regional variations in the corpus callosum and cortical gray matter Export

@article{citeulike:3244061, abstract = {To evaluate regional variations of metabolite concentrations in normal adult brain cortical gray matter regions, and the genu and splenium of the corpus callosum, using proton magnetic resonance spectroscopic imaging (MRSI).Quantitative, multislice proton MRSI (TR/TE = 2000/280 msec) was performed in 12 normal human volunteers (age = 39 ± 6 years, 7 male). Metabolite concentrations in selected cortical gray matter regions and the corpus callosum were estimated using the phantom replacement methodology.Frontal and parietal gray matter (PGM) showed strong differences in choline-containing compound (Cho) concentrations; in particular, Cho was higher in mesial frontal gray matter than in both dorsolateral prefrontal cortex (P \< 0.0005) and PGM (P \< 0.004). In contrast, both N-acetylaspartate (NAA) and creatine (Cr) were relatively uniformly distributed in the cortical gray matter regions evaluated. Significant metabolic differences were found between the genu and splenium of the corpus callosum. Cho concentrations were significantly higher in genu than splenium (P \< 0.005), while Cr was lower (P \< 0.004). NAA showed a trend to be higher in the splenium than the genu (P = 0.05).Metabolite concentrations, particularly Cho, showed strong regional variations both within cortical gray matter regions and between the genu and splenium of the corpus callosum. Mesial frontal regions showed the highest Cho signals. Differences in spectra presumably reflect underlying changes in structure and cellular composition. Normal spectral variations should always be considered when evaluating pathology within those brain regions. J. Magn. Reson. Imaging 2005;22:175-179. {\copyright} 2005 Wiley-Liss, Inc.}, address = {Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland}, author = {Degaonkar, Mahaveer N. and Pomper, Martin G. and Barker, Peter B.}, citeulike-article-id = {3244061}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jmri.20353}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/110570988/ABSTRACT}, doi = {10.1002/jmri.20353}, journal = {Journal of Magnetic Resonance Imaging}, keywords = {brain, mri, nmr, spectroscopy}, number = {2}, pages = {175--179}, posted-at = {2008-09-12 08:42:55}, priority = {2}, title = {Quantitative proton magnetic resonance spectroscopic imaging: Regional variations in the corpus callosum and cortical gray matter}, url = {http://dx.doi.org/10.1002/jmri.20353}, volume = {22}, year = {2005} }

TY - JOUR ID - citeulike:3244061 L3 - citeulike-article-id:3244061 N2 - To evaluate regional variations of metabolite concentrations in normal adult brain cortical gray matter regions, and the genu and splenium of the corpus callosum, using proton magnetic resonance spectroscopic imaging (MRSI).Quantitative, multislice proton MRSI (TR/TE = 2000/280 msec) was performed in 12 normal human volunteers (age = 39 ± 6 years, 7 male). Metabolite concentrations in selected cortical gray matter regions and the corpus callosum were estimated using the phantom replacement methodology.Frontal and parietal gray matter (PGM) showed strong differences in choline-containing compound (Cho) concentrations; in particular, Cho was higher in mesial frontal gray matter than in both dorsolateral prefrontal cortex (P < 0.0005) and PGM (P < 0.004). In contrast, both N-acetylaspartate (NAA) and creatine (Cr) were relatively uniformly distributed in the cortical gray matter regions evaluated. Significant metabolic differences were found between the genu and splenium of the corpus callosum. Cho concentrations were significantly higher in genu than splenium (P < 0.005), while Cr was lower (P < 0.004). NAA showed a trend to be higher in the splenium than the genu (P = 0.05).Metabolite concentrations, particularly Cho, showed strong regional variations both within cortical gray matter regions and between the genu and splenium of the corpus callosum. Mesial frontal regions showed the highest Cho signals. Differences in spectra presumably reflect underlying changes in structure and cellular composition. Normal spectral variations should always be considered when evaluating pathology within those brain regions. J. Magn. Reson. Imaging 2005;22:175-179. © 2005 Wiley-Liss, Inc. IS - 2 JF - Journal of Magnetic Resonance Imaging AD - Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland EP - 179 TI - Quantitative proton magnetic resonance spectroscopic imaging: Regional variations in the corpus callosum and cortical gray matter VL - 22 SP - 175 KW - brain KW - mri KW - nmr KW - spectroscopy AU - Degaonkar, Mahaveer AU - Pomper, Martin AU - Barker, Peter PY - 2005/// UR - http://dx.doi.org/10.1002/jmri.20353 ER -