P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results Export

@article{citeulike:3392502, abstract = {Abstract\ \ An original MRI contrast agent, called P792, is described. P792 is a gadolinium macrocyclic compound based on a Gd-DOTA structure substituted by hydrophilic arms. The chemical structure of P792 has been optimized in order to provide (1) a high r1 relaxivity in the clinical field for MRI: 29 mM−1 x s−1 at 60 MHz. (2) a high biocompatibility profile and (3) a high molecular volume: the apparent hydrodynamic volume of P792 is 125 times greater than that of Gd-DOTA. As a result of this high molecular volume, P792 presents an unusual pharmacokinetic profile, as it is a Rapid Clearance Blood Pool Agent (RCBPA) characterized by limited diffusion across the normal endothelium. The original pharmacokinetic properties of this RCBPA are expected to be well suited to MR coronary angiography, angiography, perfusion imaging (stress and rest), and permeability imaging (detection of ischemia and tumor grading). Further experimental imaging studies are ongoing to define the clinical value of this compound.}, author = {Port, Marc and Corot, Claire and Rousseaux, Olivier and Raynal, Isabelle and Devoldere, Ludovic and Id\'{e}e, Jean-Marc and Dencausse, Anne and Greneur, Soizic and Simonot, C. and Meyer, Dominique}, citeulike-article-id = {3392502}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/BF02668093}, day = {1}, doi = {10.1007/BF02668093}, journal = {Magnetic Resonance Materials in Physics, Biology and Medicine}, keywords = {agent, blood, contrast, mri, nmr, p792, pool}, month = {June}, number = {2}, pages = {121--127}, posted-at = {2008-10-10 07:37:31}, priority = {2}, title = {P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results}, url = {http://dx.doi.org/10.1007/BF02668093}, volume = {12}, year = {2001} }

TY - JOUR ID - citeulike:3392502 L3 - citeulike-article-id:3392502 N2 - Abstract  An original MRI contrast agent, called P792, is described. P792 is a gadolinium macrocyclic compound based on a Gd-DOTA structure substituted by hydrophilic arms. The chemical structure of P792 has been optimized in order to provide (1) a high r1 relaxivity in the clinical field for MRI: 29 mM−1 x s−1 at 60 MHz. (2) a high biocompatibility profile and (3) a high molecular volume: the apparent hydrodynamic volume of P792 is 125 times greater than that of Gd-DOTA. As a result of this high molecular volume, P792 presents an unusual pharmacokinetic profile, as it is a Rapid Clearance Blood Pool Agent (RCBPA) characterized by limited diffusion across the normal endothelium. The original pharmacokinetic properties of this RCBPA are expected to be well suited to MR coronary angiography, angiography, perfusion imaging (stress and rest), and permeability imaging (detection of ischemia and tumor grading). Further experimental imaging studies are ongoing to define the clinical value of this compound. IS - 2 JF - Magnetic Resonance Materials in Physics, Biology and Medicine EP - 127 TI - P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results VL - 12 SP - 121 KW - agent KW - blood KW - contrast KW - mri KW - nmr KW - p792 KW - pool AU - Port, Marc AU - Corot, Claire AU - Rousseaux, Olivier AU - Raynal, Isabelle AU - Devoldere, Ludovic AU - Idée, Jean-Marc AU - Dencausse, Anne AU - Greneur, Soizic AU - Simonot, C AU - Meyer, Dominique PY - 2001/06/01/ UR - http://dx.doi.org/10.1007/BF02668093 ER -