Analysis of chromosome 6q in Basque families with type 1 diabetes. GEPV-N. Basque-Navarre Endocrinology and Paediatric Group. Export

@article{citeulike:5429972, abstract = {Over the last few years several studies of linkage between non-HLA loci and type 1 diabetes mellitus have mapped several putative susceptibility genes on chromosome 6q; in fact, positive evidence of linkage and/or association of IDDM5 (6q25), IDDM8 (6q27) and IDDM15 (6q21) with type 1 diabetes has been reported. We have studied these loci in diabetic families of Basque origin, a genetically homogeneous population, to avoid artifactual association results due to admixture within the sample analysed. Statistical analyses of linkage were performed using a transmission disequilibrium test (TDT). We could not confirm linkage for IDDM5, IDDM8 and IDDM15 in our population, possibly due to population-specific differences in genetic susceptibility and/or environmental triggering factors to type 1 diabetes.}, author = {P\'{e}rez De Nanclares, G. and Bilbao, J. R. and Calvo, B. and Casta\~{n}o, L.}, citeulike-article-id = {5429972}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11204251}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11204251}, issn = {0891-6934}, journal = {Autoimmunity}, keywords = {euskal, genetika}, number = {1}, pages = {33--36}, posted-at = {2009-08-12 23:22:00}, priority = {2}, title = {Analysis of chromosome 6q in Basque families with type 1 diabetes. GEPV-N. Basque-Navarre Endocrinology and Paediatric Group.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11204251}, volume = {33}, year = {2000} }

TY - JOUR ID - citeulike:5429972 L3 - citeulike-article-id:5429972 N2 - Over the last few years several studies of linkage between non-HLA loci and type 1 diabetes mellitus have mapped several putative susceptibility genes on chromosome 6q; in fact, positive evidence of linkage and/or association of IDDM5 (6q25), IDDM8 (6q27) and IDDM15 (6q21) with type 1 diabetes has been reported. We have studied these loci in diabetic families of Basque origin, a genetically homogeneous population, to avoid artifactual association results due to admixture within the sample analysed. Statistical analyses of linkage were performed using a transmission disequilibrium test (TDT). We could not confirm linkage for IDDM5, IDDM8 and IDDM15 in our population, possibly due to population-specific differences in genetic susceptibility and/or environmental triggering factors to type 1 diabetes. IS - 1 JF - Autoimmunity SN - 0891-6934 EP - 36 TI - Analysis of chromosome 6q in Basque families with type 1 diabetes. GEPV-N. Basque-Navarre Endocrinology and Paediatric Group. VL - 33 SP - 33 KW - euskal KW - genetika AU - Pérez De Nanclares, G AU - Bilbao, JR AU - Calvo, B AU - Castaño, L PY - 2000/// UR - http://view.ncbi.nlm.nih.gov/pubmed/11204251 ER -