Structural aspects of rabies virus replication Export

@article{citeulike:3358501, abstract = {Rabies virus is a negative-strand RNA virus. Its RNA genome is condensed by the viral nucleoprotein (N), and it is this N-RNA complex that is the template for transcription and replication by the viral RNA-dependent RNA polymerase complex. Here we discuss structural and functional aspects of viral transcription and replication based on the atomic structure of a recombinant rabies virus N-RNA complex. We situate available biochemical data on N-RNA interactions with viral and cellular factors in the structural framework with regard to their implications for transcription and replication. Finally, we compare the structure of the rabies virus nucleoprotein with the structures of the nucleoproteins of vesicular stomatitis virus, Borna disease virus and influenza virus, highlighting potential similarities between these virus families.}, author = {Albertini, A. A. V. and Schoehn, G. and Weissenhorn, W. and Ruigrok, R. W. H.}, citeulike-article-id = {3358501}, citeulike-linkout-0 = {http://www.springerlink.com/content/m62837j161467347/}, journal = {Cellular and Molecular Life Sciences}, keywords = {influenza, n, nucleocapsid, nucleoprotein, p, phosphoprotein, rabies, virology, virus, vsv}, month = {January}, number = {2}, pages = {282--294}, posted-at = {2008-09-30 14:31:05}, priority = {2}, title = {Structural aspects of rabies virus replication}, url = {http://www.springerlink.com/content/m62837j161467347/}, volume = {65}, year = {2008} }

TY - JOUR ID - citeulike:3358501 L3 - citeulike-article-id:3358501 N2 - Rabies virus is a negative-strand RNA virus. Its RNA genome is condensed by the viral nucleoprotein (N), and it is this N-RNA complex that is the template for transcription and replication by the viral RNA-dependent RNA polymerase complex. Here we discuss structural and functional aspects of viral transcription and replication based on the atomic structure of a recombinant rabies virus N-RNA complex. We situate available biochemical data on N-RNA interactions with viral and cellular factors in the structural framework with regard to their implications for transcription and replication. Finally, we compare the structure of the rabies virus nucleoprotein with the structures of the nucleoproteins of vesicular stomatitis virus, Borna disease virus and influenza virus, highlighting potential similarities between these virus families. IS - 2 JF - Cellular and Molecular Life Sciences EP - 294 TI - Structural aspects of rabies virus replication VL - 65 SP - 282 KW - influenza KW - n KW - nucleocapsid KW - nucleoprotein KW - p KW - phosphoprotein KW - rabies KW - virology KW - virus KW - vsv AU - Albertini, AAV AU - Schoehn, G AU - Weissenhorn, W AU - Ruigrok, RWH PY - 2008/01// UR - http://www.springerlink.com/content/m62837j161467347/ ER -