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Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

by: Grace S. Crowther, Simon D. Baines, Sharie L. Todhunter, Jane Freeman, Caroline H. Chilton, Mark H. Wilcox
Journal of Antimicrobial Chemotherapy, Vol. 68, No. 1. (01 January 2013), pp. 168-176, doi:10.1093/jac/dks359  Key: citeulike:11860918

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Abstract

Objectives First-line treatment options for Clostridium difficile infection (CDI) are limited. NVB302 is a novel type B lantibiotic under evaluation for the treatment of CDI. We compared the responses to NVB302 and vancomycin when used to treat simulated CDI in an in vitro gut model.


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