Molecular definition of breast tumor heterogeneity. Export

@article{citeulike:1435722, abstract = {Cells with distinct phenotypes including stem-cell-like properties have been proposed to exist in normal human mammary epithelium and breast carcinomas, but their detailed molecular characteristics and clinical significance are unclear. We determined gene expression and genetic profiles of cells purified from cancerous and normal breast tissue using markers previously associated with stem-cell-like properties. CD24+ and CD44+ cells from individual tumors were clonally related but not always identical. CD44+ cell-specific genes included many known stem-cell markers and correlated with decreased patient survival. The TGF-beta pathway was specifically active in CD44+ cancer cells, where its inhibition induced a more epithelial phenotype. Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations.}, address = {Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.}, author = {Shipitsin, M. and Campbell, L. L. and Argani, P. and Weremowicz, S. and Bloushtain-Qimron, N. and Yao, J. and Nikolskaya, T. and Serebryiskaya, T. and Beroukhim, R. and Hu, M. and Halushka, M. K. and Sukumar, S. and Parker, L. M. and Anderson, K. S. and Harris, L. N. and Garber, J. E. and Richardson, A. L. and Schnitt, S. J. and Nikolsky, Y. and Gelman, R. S. and Polyak, K.}, citeulike-article-id = {1435722}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2007.01.013}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17349583}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17349583}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WWK-4N7RR76-7/2/243afbb9ba1e3debadd978cf443c948d}, doi = {10.1016/j.ccr.2007.01.013}, issn = {1535-6108}, journal = {Cancer Cell}, keywords = {breast, cancer, cd44, check, heterogeneity-bc, thelist}, month = {March}, number = {3}, pages = {259--273}, posted-at = {2009-04-21 13:50:22}, priority = {2}, title = {Molecular definition of breast tumor heterogeneity.}, url = {http://dx.doi.org/10.1016/j.ccr.2007.01.013}, volume = {11}, year = {2007} }

TY - JOUR ID - citeulike:1435722 L3 - citeulike-article-id:1435722 N2 - Cells with distinct phenotypes including stem-cell-like properties have been proposed to exist in normal human mammary epithelium and breast carcinomas, but their detailed molecular characteristics and clinical significance are unclear. We determined gene expression and genetic profiles of cells purified from cancerous and normal breast tissue using markers previously associated with stem-cell-like properties. CD24+ and CD44+ cells from individual tumors were clonally related but not always identical. CD44+ cell-specific genes included many known stem-cell markers and correlated with decreased patient survival. The TGF-beta pathway was specifically active in CD44+ cancer cells, where its inhibition induced a more epithelial phenotype. Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations. IS - 3 JF - Cancer Cell SN - 1535-6108 AD - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. EP - 273 TI - Molecular definition of breast tumor heterogeneity. VL - 11 SP - 259 KW - breast KW - cancer KW - cd44 KW - check KW - heterogeneity-bc KW - thelist AU - Shipitsin, M AU - Campbell, LL AU - Argani, P AU - Weremowicz, S AU - Bloushtain-Qimron, N AU - Yao, J AU - Nikolskaya, T AU - Serebryiskaya, T AU - Beroukhim, R AU - Hu, M AU - Halushka, MK AU - Sukumar, S AU - Parker, LM AU - Anderson, KS AU - Harris, LN AU - Garber, JE AU - Richardson, AL AU - Schnitt, SJ AU - Nikolsky, Y AU - Gelman, RS AU - Polyak, K PY - 2007/03// UR - http://dx.doi.org/10.1016/j.ccr.2007.01.013 ER -