Histopathologic indicators of breast cancer biology: insights from population mammographic screening Export

@article{citeulike:150012, abstract = {Histopathologic features of breast cancer such as tumour size, grade and axillary lymph node (LN) status variably reflect tumour biology and time. Recent evidence suggests that the biological character of breast cancer is established at an early stage and has a major impact on clinical course. The aim of this study was to distinguish the impact of biology on breast cancer histopathology by comparing features of breast cancers diagnosed following population mammographic screening with prevalent vs incident detection and screening interval. Central histopathology review data from 1147 cases of ductal in situ and/or invasive breast cancer were examined. Size, grade and LN status of invasive cancers were positively correlated (P < 0.001). Prevalent invasive cancers were larger (P < 0.001) and more likely to be LN positive (P = 0.02) than incident cases, but grade was not associated with screening episode (P = 0.7). Screening interval for incident cancers was positively associated with invasive cancer size (P = 0.05) and LN status (P = 0.002) but not grade (P = 0.1). Together, these data indicate that biology and time both impact on size and LN status of invasive breast cancer, but grade reflects biology alone. In view of the clinical importance of breast cancer biology, grade as its most direct indicator assumes particular significance.}, author = {Webster, L. R. and Bilous, A. M. and Willis, L. and Byth, K. and Burgemeister, F. C. and Salisbury, E. L. C. and Clarke, C. L. and Balleine, R. L.}, citeulike-article-id = {150012}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.bjc.6602501}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15812557}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15812557}, day = {05}, doi = {10.1038/sj.bjc.6602501}, issn = {0007-0920}, journal = {British Journal of Cancer}, keywords = {aggressiveness, biology, breast, cancer, check, grade, superlist, thelist, webster}, month = {April}, number = {current}, posted-at = {2009-06-05 15:18:21}, priority = {2}, publisher = {Nature Publishing Group}, title = {Histopathologic indicators of breast cancer biology: insights from population mammographic screening}, url = {http://dx.doi.org/10.1038/sj.bjc.6602501}, volume = {aop}, year = {2005} }

TY - JOUR ID - citeulike:150012 L3 - citeulike-article-id:150012 N2 - Histopathologic features of breast cancer such as tumour size, grade and axillary lymph node (LN) status variably reflect tumour biology and time. Recent evidence suggests that the biological character of breast cancer is established at an early stage and has a major impact on clinical course. The aim of this study was to distinguish the impact of biology on breast cancer histopathology by comparing features of breast cancers diagnosed following population mammographic screening with prevalent vs incident detection and screening interval. Central histopathology review data from 1147 cases of ductal in situ and/or invasive breast cancer were examined. Size, grade and LN status of invasive cancers were positively correlated (P < 0.001). Prevalent invasive cancers were larger (P < 0.001) and more likely to be LN positive (P = 0.02) than incident cases, but grade was not associated with screening episode (P = 0.7). Screening interval for incident cancers was positively associated with invasive cancer size (P = 0.05) and LN status (P = 0.002) but not grade (P = 0.1). Together, these data indicate that biology and time both impact on size and LN status of invasive breast cancer, but grade reflects biology alone. In view of the clinical importance of breast cancer biology, grade as its most direct indicator assumes particular significance. IS - current JF - British Journal of Cancer SN - 0007-0920 TI - Histopathologic indicators of breast cancer biology: insights from population mammographic screening PB - Nature Publishing Group VL - aop KW - aggressiveness KW - biology KW - breast KW - cancer KW - check KW - grade KW - superlist KW - thelist KW - webster AU - Webster, LR AU - Bilous, AM AU - Willis, L AU - Byth, K AU - Burgemeister, FC AU - Salisbury, ELC AU - Clarke, CL AU - Balleine, RL PY - 2005/04/05/ UR - http://dx.doi.org/10.1038/sj.bjc.6602501 ER -