Illuminating the metastatic process Export

@article{citeulike:1747761, abstract = {Until recently most studies of metastasis only measured the end point of the process--macroscopic metastases. Although these studies have provided much useful information, the details of the metastatic process remain somewhat mysterious owing to difficulties in studying cell behaviour with high spatial and temporal resolution in vivo. The use of luminescent and fluorescent proteins and developments in optical imaging technology have enabled the direct observation of cancer cells spreading from their site of origin and arriving at secondary sites. This Review will describe recent advances in our understanding of the different steps of metastasis gained from cellular resolution imaging, and how these techniques can be used in preclinical drug evaluation.}, author = {Sahai, Erik}, citeulike-article-id = {1747761}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrc2229}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrc2229}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17891189}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17891189}, doi = {10.1038/nrc2229}, journal = {Nat Rev Cancer}, keywords = {advances, cancer, cancer-crosstalk, development, metastasis, review, technology}, month = {October}, number = {10}, pages = {737--749}, posted-at = {2009-01-31 00:07:17}, priority = {2}, title = {Illuminating the metastatic process}, url = {http://dx.doi.org/10.1038/nrc2229}, volume = {7}, year = {2007} }

TY - JOUR ID - citeulike:1747761 L3 - citeulike-article-id:1747761 N2 - Until recently most studies of metastasis only measured the end point of the process--macroscopic metastases. Although these studies have provided much useful information, the details of the metastatic process remain somewhat mysterious owing to difficulties in studying cell behaviour with high spatial and temporal resolution in vivo. The use of luminescent and fluorescent proteins and developments in optical imaging technology have enabled the direct observation of cancer cells spreading from their site of origin and arriving at secondary sites. This Review will describe recent advances in our understanding of the different steps of metastasis gained from cellular resolution imaging, and how these techniques can be used in preclinical drug evaluation. IS - 10 JF - Nat Rev Cancer EP - 749 TI - Illuminating the metastatic process VL - 7 SP - 737 KW - advances KW - cancer KW - cancer-crosstalk KW - development KW - metastasis KW - review KW - technology AU - Sahai, Erik PY - 2007/10// UR - http://dx.doi.org/10.1038/nrc2229 ER -