Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology Export

@article{citeulike:2486297, abstract = {During the last years, a series of studies on combinations of oestrogenic, thyroid-disrupting and anti-androgenic chemicals at low doses have been published. The available experimental evidence shows that combination effects may result from endocrine disrupters that each produces very small effects, if they are present in sufficiently large numbers. This review examines the implications of these findings for chemicals risk assessment and epidemiology. It is concluded that a lack of knowledge about relevant exposure scenarios presents serious obstacles for better human risk assessment. Epidemiology needs to abandon its focus on single endocrine disrupters and has to embrace the reality of endocrine disrupter mixture effects by developing biomarkers that capture cumulative exposure to endocrine disrupters.}, author = {Kortenkamp and Andreas}, citeulike-article-id = {2486297}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1365-2605.2007.00862.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/bsc/ija/2008/00000031/00000002/art00022}, citeulike-linkout-2 = {http://www3.interscience.wiley.com/cgi-bin/abstract/119398217/ABSTRACT}, doi = {10.1111/j.1365-2605.2007.00862.x}, issn = {0105-6263}, journal = {International Journal of Andrology}, keywords = {additive, breast, cancer, disruption, dod, endocrine, justification, low-dose, mixture-effects, risk, strengths, thelist}, month = {April}, number = {2}, pages = {233--240}, posted-at = {2008-11-24 22:55:29}, priority = {2}, publisher = {Blackwell Publishing}, title = {Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology}, url = {http://dx.doi.org/10.1111/j.1365-2605.2007.00862.x}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2486297 L3 - citeulike-article-id:2486297 N2 - During the last years, a series of studies on combinations of oestrogenic, thyroid-disrupting and anti-androgenic chemicals at low doses have been published. The available experimental evidence shows that combination effects may result from endocrine disrupters that each produces very small effects, if they are present in sufficiently large numbers. This review examines the implications of these findings for chemicals risk assessment and epidemiology. It is concluded that a lack of knowledge about relevant exposure scenarios presents serious obstacles for better human risk assessment. Epidemiology needs to abandon its focus on single endocrine disrupters and has to embrace the reality of endocrine disrupter mixture effects by developing biomarkers that capture cumulative exposure to endocrine disrupters. IS - 2 JF - International Journal of Andrology SN - 0105-6263 EP - 240 TI - Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology PB - Blackwell Publishing VL - 31 SP - 233 KW - additive KW - breast KW - cancer KW - disruption KW - dod KW - endocrine KW - justification KW - low-dose KW - mixture-effects KW - risk KW - strengths KW - thelist AU - Kortenkamp AU - Andreas PY - 2008/04// UR - http://dx.doi.org/10.1111/j.1365-2605.2007.00862.x ER -