TGF-Beta in Cancer Export

@article{citeulike:3083557, abstract = {The transforming growth factor [beta] (TGF[beta]) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development. The regulatory cytokine TGF[beta] exerts tumor-suppressive effects that cancer cells must elude for malignant evolution. Yet, paradoxically, TGF[beta] also modulates processes such as cell invasion, immune regulation, and microenvironment modification that cancer cells may exploit to their advantage. Consequently, the output of a TGF[beta] response is highly contextual throughout development, across different tissues, and also in cancer. The mechanistic basis and clinical relevance of TGF[beta]'s role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.}, author = {Massague, J.}, citeulike-article-id = {3083557}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2008.07.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867408008787}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18662538}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18662538}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WSN-4T2C0K7-9/2/89d775a4667728f23ca4b1e581e69054}, day = {25}, doi = {10.1016/j.cell.2008.07.001}, issn = {0092-8674}, journal = {Cell}, keywords = {cancer, review, superlist, tgfb}, month = {July}, number = {2}, pages = {215--230}, posted-at = {2009-07-26 17:48:22}, priority = {2}, title = {TGF-Beta in Cancer}, url = {http://dx.doi.org/10.1016/j.cell.2008.07.001}, volume = {134}, year = {2008} }

TY - JOUR ID - citeulike:3083557 L3 - citeulike-article-id:3083557 N2 - The transforming growth factor [beta] (TGF[beta]) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development. The regulatory cytokine TGF[beta] exerts tumor-suppressive effects that cancer cells must elude for malignant evolution. Yet, paradoxically, TGF[beta] also modulates processes such as cell invasion, immune regulation, and microenvironment modification that cancer cells may exploit to their advantage. Consequently, the output of a TGF[beta] response is highly contextual throughout development, across different tissues, and also in cancer. The mechanistic basis and clinical relevance of TGF[beta]'s role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway. IS - 2 JF - Cell SN - 0092-8674 EP - 230 TI - TGF-Beta in Cancer VL - 134 SP - 215 KW - cancer KW - review KW - superlist KW - tgfb AU - Massague, J PY - 2008/07/25/ UR - http://dx.doi.org/10.1016/j.cell.2008.07.001 ER -