Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women Export

@article{citeulike:3129529, abstract = {Epidermal growth factor receptor (EGFR) and c-kit are tyrosine kinase growth factor receptors which are frequently expressed in basal-like breast carcinomas, and tyrosine kinase inhibition is now a promising strategy in treatment of breast cancer. The aim of this study was to evaluate the expression of EGFR and c-kit in breast cancer with special focus on the basal-like phenotype (BLP) and other prognostic factors in an African population. We analyzed 65 archival tissues immunohistologically. EGFR and/or c-kit were expressed in 55\% of basal-like tumors. Expression of EGFR and/or c-kit was strongly associated with high histologic grade (P=0.001), high nuclear grade (P=0.017), high mitotic counts (P=0.002), ER negativity (P=0.003), PR negativity (P=0.007), and HER2 negativity (P=0.014). EGFR and/or c-kit positive tumors were more likely to express the BLP (OR 9.1, CI 2.6–32.0, P<0.0005) than the negative tumors. In conclusion, there is a high expression of EGFR and/or c-kit in basal-like breast carcinoma in this series from Uganda and their expression is associated with features of poor prognosis. More studies are required to assess the clinical significance of EGFR and c-kit in breast cancer patients in Uganda.}, author = {Arnes, Jarle B. and Wabinga, Henry and Akslen, Lars A. and Nalwoga, H. A. W. A.}, citeulike-article-id = {3129529}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1600-0463.2008.01024.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/mksg/apm/2008/00000116/00000006/art00009}, citeulike-linkout-2 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121377982/ABSTRACT}, doi = {10.1111/j.1600-0463.2008.01024.x}, issn = {0903-4641}, journal = {Apmis}, keywords = {africa, breast, c-kit, cancer, egfr, prognosis, thelist, uganda}, month = {June}, number = {6}, pages = {515--525}, posted-at = {2008-11-24 01:31:42}, priority = {2}, publisher = {Blackwell Publishing}, title = {Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women}, url = {http://dx.doi.org/10.1111/j.1600-0463.2008.01024.x}, volume = {116}, year = {2008} }

TY - JOUR ID - citeulike:3129529 L3 - citeulike-article-id:3129529 N2 - Epidermal growth factor receptor (EGFR) and c-kit are tyrosine kinase growth factor receptors which are frequently expressed in basal-like breast carcinomas, and tyrosine kinase inhibition is now a promising strategy in treatment of breast cancer. The aim of this study was to evaluate the expression of EGFR and c-kit in breast cancer with special focus on the basal-like phenotype (BLP) and other prognostic factors in an African population. We analyzed 65 archival tissues immunohistologically. EGFR and/or c-kit were expressed in 55% of basal-like tumors. Expression of EGFR and/or c-kit was strongly associated with high histologic grade (P=0.001), high nuclear grade (P=0.017), high mitotic counts (P=0.002), ER negativity (P=0.003), PR negativity (P=0.007), and HER2 negativity (P=0.014). EGFR and/or c-kit positive tumors were more likely to express the BLP (OR 9.1, CI 2.6–32.0, P<0.0005) than the negative tumors. In conclusion, there is a high expression of EGFR and/or c-kit in basal-like breast carcinoma in this series from Uganda and their expression is associated with features of poor prognosis. More studies are required to assess the clinical significance of EGFR and c-kit in breast cancer patients in Uganda. IS - 6 JF - Apmis SN - 0903-4641 EP - 525 TI - Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women PB - Blackwell Publishing VL - 116 SP - 515 KW - africa KW - breast KW - c-kit KW - cancer KW - egfr KW - prognosis KW - thelist KW - uganda AU - Arnes, Jarle AU - Wabinga, Henry AU - Akslen, Lars AU - Nalwoga, HAWA PY - 2008/06// UR - http://dx.doi.org/10.1111/j.1600-0463.2008.01024.x ER -