Gene expression profiles of human breast cancer progression. Export

@article{citeulike:3387864, abstract = {Although distinct pathological stages of breast cancer have been described, the molecular differences among these stages are largely unknown. Here, through the combined use of laser capture microdissection and DNA microarrays, we have generated in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer. Our data reveal extensive similarities at the transcriptome level among the distinct stages of progression and suggest that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stages. In contrast to tumor stage, different tumor grades are associated with distinct gene expression signatures. Furthermore, a subset of genes associated with high tumor grade is quantitatively correlated with the transition from preinvasive to invasive growth.}, author = {Ma, X. J. and Salunga, R. and Tuggle, J. T. and Gaudet, J. and Enright, E. and McQuary, P. and Payette, T. and Pistone, M. and Stecker, K. and Zhang, B. M. and Zhou, Y. X. and Varnholt, H. and Smith, B. and Gadd, M. and Chatfield, E. and Kessler, J. and Baer, T. M. and Erlander, M. G. and Sgroi, D. C.}, citeulike-article-id = {3387864}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0931261100}, citeulike-linkout-1 = {http://www.pnas.org/content/100/10/5974.long.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/100/10/5974.long.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/12714683}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=12714683}, day = {13}, doi = {10.1073/pnas.0931261100}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {breast, cancer, defref, dod, gene-expression, irb, microenvironment, progression, superlist, thelist, urgent}, month = {May}, number = {10}, pages = {5974--5979}, posted-at = {2009-05-06 16:34:33}, priority = {2}, title = {Gene expression profiles of human breast cancer progression.}, url = {http://dx.doi.org/10.1073/pnas.0931261100}, volume = {100}, year = {2003} }

TY - JOUR ID - citeulike:3387864 L3 - citeulike-article-id:3387864 N2 - Although distinct pathological stages of breast cancer have been described, the molecular differences among these stages are largely unknown. Here, through the combined use of laser capture microdissection and DNA microarrays, we have generated in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer. Our data reveal extensive similarities at the transcriptome level among the distinct stages of progression and suggest that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stages. In contrast to tumor stage, different tumor grades are associated with distinct gene expression signatures. Furthermore, a subset of genes associated with high tumor grade is quantitatively correlated with the transition from preinvasive to invasive growth. IS - 10 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 5979 TI - Gene expression profiles of human breast cancer progression. VL - 100 SP - 5974 KW - breast KW - cancer KW - defref KW - dod KW - gene-expression KW - irb KW - microenvironment KW - progression KW - superlist KW - thelist KW - urgent AU - Ma, XJ AU - Salunga, R AU - Tuggle, JT AU - Gaudet, J AU - Enright, E AU - McQuary, P AU - Payette, T AU - Pistone, M AU - Stecker, K AU - Zhang, BM AU - Zhou, YX AU - Varnholt, H AU - Smith, B AU - Gadd, M AU - Chatfield, E AU - Kessler, J AU - Baer, TM AU - Erlander, MG AU - Sgroi, DC PY - 2003/05/13/ UR - http://dx.doi.org/10.1073/pnas.0931261100 ER -