Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

@article{citeulike:3398894, abstract = {Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved.}, author = {Crain, D. and Janssen, S. and Edwards, T. and Heindel, J. and Ho, S. and Hunt, P. and Iguchi, T. and Juul, A. and Mclachlan, J. and Schwartz, J.}, citeulike-article-id = {3398894}, doi = {10.1016/j.fertnstert.2008.08.067}, issn = {00150282}, journal = {Fertility and Sterility}, keywords = {breast, cancer, disruption, endocrine, review, thesis, xenoestrogen}, month = {October}, number = {4}, pages = {911--940}, posted-at = {2008-10-13 03:11:18}, priority = {2}, title = {Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing}, url = {http://dx.doi.org/10.1016/j.fertnstert.2008.08.067}, volume = {90}, year = {2008} }

TY - JOUR ID - citeulike:3398894 L3 - citeulike-article-id:3398894 N2 - Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved. IS - 4 JF - Fertility and Sterility SN - 00150282 EP - 940 TI - Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing VL - 90 SP - 911 KW - breast KW - cancer KW - disruption KW - endocrine KW - review KW - thesis KW - xenoestrogen AU - Crain, D AU - Janssen, S AU - Edwards, T AU - Heindel, J AU - Ho, S AU - Hunt, P AU - Iguchi, T AU - Juul, A AU - Mclachlan, J AU - Schwartz, J PY - 2008/10// UR - http://dx.doi.org/10.1016/j.fertnstert.2008.08.067 ER -