DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype. Export

@article{citeulike:3416179, abstract = {We have engineered a DNA epitope vaccine that expresses 3 self-B cell epitopes of Abeta(42) (3Abeta(1-11)), a non-self T helper (Th) cell epitope (PADRE), and 3 copies of C3d (3C3d), a component of complement as a molecular adjuvant, designed to safely reduce CNS Abeta. Immunization of mice with 3Abeta(1-11)-PADRE epitope vaccine alone generated only moderate levels of anti-Abeta antibodies and a pro-inflammatory T helper (Th1 phenotype) cellular immune response. However, the addition of 3C3d to the vaccine construct significantly augmented the anti-Abeta humoral immune response and, importantly, shifted the cellular immune response towards the potentially safer anti-inflammatory Th2 phenotype.}, author = {Movsesyan, Nina and Mkrtichyan, Mikayel and Petrushina, Irina and Ross, Ted M M. and Cribbs, David H H. and Agadjanyan, Michael G G. and Ghochikyan, Anahit}, citeulike-article-id = {3416179}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jneuroim.2008.08.016}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18838175}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18838175}, day = {4}, doi = {10.1016/j.jneuroim.2008.08.016}, issn = {0165-5728}, journal = {Journal of neuroimmunology}, keywords = {anti-inflammatory, balance, confounder, dna, superlist, th1, th2, thelist, vaccine}, month = {October}, posted-at = {2008-10-16 02:00:56}, priority = {2}, title = {DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype.}, url = {http://dx.doi.org/10.1016/j.jneuroim.2008.08.016}, year = {2008} }

TY - JOUR ID - citeulike:3416179 L3 - citeulike-article-id:3416179 N2 - We have engineered a DNA epitope vaccine that expresses 3 self-B cell epitopes of Abeta(42) (3Abeta(1-11)), a non-self T helper (Th) cell epitope (PADRE), and 3 copies of C3d (3C3d), a component of complement as a molecular adjuvant, designed to safely reduce CNS Abeta. Immunization of mice with 3Abeta(1-11)-PADRE epitope vaccine alone generated only moderate levels of anti-Abeta antibodies and a pro-inflammatory T helper (Th1 phenotype) cellular immune response. However, the addition of 3C3d to the vaccine construct significantly augmented the anti-Abeta humoral immune response and, importantly, shifted the cellular immune response towards the potentially safer anti-inflammatory Th2 phenotype. JF - Journal of neuroimmunology SN - 0165-5728 TI - DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype. KW - anti-inflammatory KW - balance KW - confounder KW - dna KW - superlist KW - th1 KW - th2 KW - thelist KW - vaccine AU - Movsesyan, Nina AU - Mkrtichyan, Mikayel AU - Petrushina, Irina AU - Ross, Ted M AU - Cribbs, David H AU - Agadjanyan, Michael G AU - Ghochikyan, Anahit PY - 2008/10/04/ UR - http://dx.doi.org/10.1016/j.jneuroim.2008.08.016 ER -