Shared biology of GVHD and GVT effects: Potential methods of separation Export

@article{citeulike:3422622, abstract = {The difficult separation of clinical graft-versus-tumor (GVT) effects from graft-versus-host disease (GVHD) reflects their shared biology. Experimental approaches to mediate GVT effects while limiting GVHD include: (1) allograft T cell depletion followed by immune enhancement; (2) modulation of T cell dose or T cell subset composition; (3) donor lymphocyte infusion; (4) reduced-intensity host preparation; (5) modulation of Th1/Th2 and Tc1/Tc2 cell balance; (6) cytokine therapy or neutralization; (7) T regulatory cell therapy; (8) co-stimulatory pathway modulation; (9) chemokine pathway modulation; (10) induction of antigen-specific T cells; (11) alloreactive NK cell therapy; and (12) targeted pharmaceutical inhibition of proteosome, mammalian target of rapamycin, and histone deacetylase pathways. Clearly, a multitude of approaches exist that hold promise for separating GVT effects from GVHD. Future success in this endeavor will require a strong commitment towards translational research and continued advances in cell, vaccine, cytokine, monoclonal antibody, and targeted molecular therapy.}, author = {Fowler, D.}, citeulike-article-id = {3422622}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.critrevonc.2005.07.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1040842805001472}, doi = {10.1016/j.critrevonc.2005.07.001}, issn = {10408428}, journal = {Critical Reviews in Oncology/Hematology}, keywords = {disease, graft, host, superlist, t-cell, th1, th2, thelist, transplantation, tumour}, month = {March}, number = {3}, pages = {225--244}, posted-at = {2008-10-16 23:59:59}, priority = {2}, title = {Shared biology of GVHD and GVT effects: Potential methods of separation}, url = {http://dx.doi.org/10.1016/j.critrevonc.2005.07.001}, volume = {57}, year = {2006} }

TY - JOUR ID - citeulike:3422622 L3 - citeulike-article-id:3422622 N2 - The difficult separation of clinical graft-versus-tumor (GVT) effects from graft-versus-host disease (GVHD) reflects their shared biology. Experimental approaches to mediate GVT effects while limiting GVHD include: (1) allograft T cell depletion followed by immune enhancement; (2) modulation of T cell dose or T cell subset composition; (3) donor lymphocyte infusion; (4) reduced-intensity host preparation; (5) modulation of Th1/Th2 and Tc1/Tc2 cell balance; (6) cytokine therapy or neutralization; (7) T regulatory cell therapy; (8) co-stimulatory pathway modulation; (9) chemokine pathway modulation; (10) induction of antigen-specific T cells; (11) alloreactive NK cell therapy; and (12) targeted pharmaceutical inhibition of proteosome, mammalian target of rapamycin, and histone deacetylase pathways. Clearly, a multitude of approaches exist that hold promise for separating GVT effects from GVHD. Future success in this endeavor will require a strong commitment towards translational research and continued advances in cell, vaccine, cytokine, monoclonal antibody, and targeted molecular therapy. IS - 3 JF - Critical Reviews in Oncology/Hematology SN - 10408428 EP - 244 TI - Shared biology of GVHD and GVT effects: Potential methods of separation VL - 57 SP - 225 KW - disease KW - graft KW - host KW - superlist KW - t-cell KW - th1 KW - th2 KW - thelist KW - transplantation KW - tumour AU - Fowler, D PY - 2006/03// UR - http://dx.doi.org/10.1016/j.critrevonc.2005.07.001 ER -