Relationship between adenosine and T-helper 1/T-helper 2 balance in hyperemesis gravidarum. Export

@article{citeulike:3422837, abstract = {BACKGROUND: Adenosine modulates the T-helper (Th) 1/T-helper (Th) 2 balance. We evaluated the relationship between changes in plasma adenosine and the T-helper (Th) 1/T-helper (Th) 2 balance in hyperemesis gravidarum. METHODS: Plasma adenosine concentrations and the Th1/Th2 ratio were examined in the peripheral blood of 24 women with hyperemesis gravidarum and normal pregnancies. The proportion of CD4-positive cells that expressed intracellular cytokines (interferon gamma and interleukin 4) was analyzed by flow cytometry. The ratio of interferon-gamma-secreting cells to interleukin-4-secreting cells was taken as the Th1/Th2 ratio in vivo. The change induced by adenosine-receptor blocker 8-sulfophenyltheophylline was also measured in vitro to evaluate the possible role of adenosine in modifying the Th1/Th2 balance. RESULTS: In hyperemesis gravidarum, plasma adenosine and the proportion of interleukin-4-secreting cells were increased significantly, and the Th1/Th2 ratio was significantly lower than in normal pregnancy (p<0.05). The decrease in the proportion of IL-4-secreting cells after adenosine receptor blockade in hyperemesis gravidarum significantly exceeded that of normal pregnancy (p<0.05). CONCLUSIONS: Increased plasma adenosine may be involved in regulating the Th1/Th2 balance in hyperemesis gravidarum.}, author = {Kiyokawa, Y. and Yoneyama, Y.}, citeulike-article-id = {3422837}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cca.2006.02.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16616909}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16616909}, doi = {10.1016/j.cca.2006.02.001}, issn = {0009-8981}, journal = {Clinica chimica acta; international journal of clinical chemistry}, keywords = {adenosine, balance, gravidarum, hyperemesis, superlist, th1, th2, thelist, usage}, month = {August}, number = {1-2}, pages = {137--142}, posted-at = {2008-10-17 02:32:35}, priority = {2}, title = {Relationship between adenosine and T-helper 1/T-helper 2 balance in hyperemesis gravidarum.}, url = {http://dx.doi.org/10.1016/j.cca.2006.02.001}, volume = {370}, year = {2006} }

TY - JOUR ID - citeulike:3422837 L3 - citeulike-article-id:3422837 N2 - BACKGROUND: Adenosine modulates the T-helper (Th) 1/T-helper (Th) 2 balance. We evaluated the relationship between changes in plasma adenosine and the T-helper (Th) 1/T-helper (Th) 2 balance in hyperemesis gravidarum. METHODS: Plasma adenosine concentrations and the Th1/Th2 ratio were examined in the peripheral blood of 24 women with hyperemesis gravidarum and normal pregnancies. The proportion of CD4-positive cells that expressed intracellular cytokines (interferon gamma and interleukin 4) was analyzed by flow cytometry. The ratio of interferon-gamma-secreting cells to interleukin-4-secreting cells was taken as the Th1/Th2 ratio in vivo. The change induced by adenosine-receptor blocker 8-sulfophenyltheophylline was also measured in vitro to evaluate the possible role of adenosine in modifying the Th1/Th2 balance. RESULTS: In hyperemesis gravidarum, plasma adenosine and the proportion of interleukin-4-secreting cells were increased significantly, and the Th1/Th2 ratio was significantly lower than in normal pregnancy (p<0.05). The decrease in the proportion of IL-4-secreting cells after adenosine receptor blockade in hyperemesis gravidarum significantly exceeded that of normal pregnancy (p<0.05). CONCLUSIONS: Increased plasma adenosine may be involved in regulating the Th1/Th2 balance in hyperemesis gravidarum. IS - 1-2 JF - Clinica chimica acta; international journal of clinical chemistry SN - 0009-8981 EP - 142 TI - Relationship between adenosine and T-helper 1/T-helper 2 balance in hyperemesis gravidarum. VL - 370 SP - 137 KW - adenosine KW - balance KW - gravidarum KW - hyperemesis KW - superlist KW - th1 KW - th2 KW - thelist KW - usage AU - Kiyokawa, Y AU - Yoneyama, Y PY - 2006/08// UR - http://dx.doi.org/10.1016/j.cca.2006.02.001 ER -