Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells Export

@article{citeulike:3444406, abstract = {Abstract  If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.}, author = {Ono\'{e}, Kazunori and Yanagawa, Yoshiki and Minami, Keita and Iijima, Norifumi and Iwabuchi, Kazuya}, citeulike-article-id = {3444406}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s12026-007-0011-5}, day = {1}, doi = {10.1007/s12026-007-0011-5}, issn = {1559-0755}, journal = {Immunologic Research}, keywords = {balance, confounder, dendritic, nkt-cells, polarization, superlist, th1, th2, thelist}, month = {June}, number = {1-3}, pages = {319--332}, posted-at = {2008-10-23 20:35:47}, priority = {2}, title = {Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells}, url = {http://dx.doi.org/10.1007/s12026-007-0011-5}, volume = {38}, year = {2007} }

TY - JOUR ID - citeulike:3444406 L3 - citeulike-article-id:3444406 N2 - Abstract  If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders. IS - 1-3 JF - Immunologic Research SN - 1559-0755 EP - 332 TI - Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells VL - 38 SP - 319 KW - balance KW - confounder KW - dendritic KW - nkt-cells KW - polarization KW - superlist KW - th1 KW - th2 KW - thelist AU - Onoé, Kazunori AU - Yanagawa, Yoshiki AU - Minami, Keita AU - Iijima, Norifumi AU - Iwabuchi, Kazuya PY - 2007/06/01/ UR - http://dx.doi.org/10.1007/s12026-007-0011-5 ER -