Epidemiology of basal-like breast cancer Export

@article{citeulike:3459688, abstract = {Risk factors for the newly identified "intrinsic" breast cancer subtypes (luminal A, luminal B, basal-like and human epidermal growth factor receptor 2-positive/estrogen receptor-negative) were determined in the Carolina Breast Cancer Study, a population-based, case-control study of African-American and white women. Immunohistochemical markers were used to subtype 1,424 cases of invasive and in situ breast cancer, and case subtypes were compared to 2,022 controls. Luminal A, the most common subtype, exhibited risk factors typically reported for breast cancer in previous studies, including inverse associations for increased parity and younger age at first full-term pregnancy. Basal-like cases exhibited several associations that were opposite to those observed for luminal A, including increased risk for parity and younger age at first term full-term pregnancy. Longer duration breastfeeding, increasing number of children breastfed, and increasing number of months breastfeeding per child were each associated with reduced risk of basal-like breast cancer, but not luminal A. Women with multiple live births who did not breastfeed and women who used medications to suppress lactation were at increased risk of basal-like, but not luminal A, breast cancer. Elevated waist-hip ratio was associated with increased risk of luminal A in postmenopausal women, and increased risk of basal-like breast cancer in pre- and postmenopausal women. The prevalence of basal-like breast cancer was highest among premenopausal African-American women, who also showed the highest prevalence of basal-like risk factors. Among younger African-American women, we estimate that up to 68\% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity.}, author = {Millikan, Robert C. and Newman, Beth and Tse, Chiu-Kit and Moorman, Patricia G. and Conway, Kathleen and Smith, Lisa V. and Labbok, Miriam H. and Geradts, Joseph and Bensen, Jeannette T. and Jackson, Susan and Nyante, Sarah and Livasy, Chad and Carey, Lisa and Earp, Shelton H. and Perou, Charles M.}, citeulike-article-id = {3459688}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s10549-007-9632-6}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17578664}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17578664}, citeulike-linkout-3 = {http://www.springerlink.com/content/h749w061034h7655}, doi = {10.1007/s10549-007-9632-6}, issn = {1573-7217}, journal = {Breast Cancer Research and Treatment}, keywords = {basal, breast, cancer, carolina, superlist, thelist}, month = {June}, number = {1}, pages = {123--139}, posted-at = {2008-12-02 07:29:34}, priority = {2}, title = {Epidemiology of basal-like breast cancer}, url = {http://dx.doi.org/10.1007/s10549-007-9632-6}, volume = {109}, year = {2007} }

TY - JOUR ID - citeulike:3459688 L3 - citeulike-article-id:3459688 N2 - Risk factors for the newly identified "intrinsic" breast cancer subtypes (luminal A, luminal B, basal-like and human epidermal growth factor receptor 2-positive/estrogen receptor-negative) were determined in the Carolina Breast Cancer Study, a population-based, case-control study of African-American and white women. Immunohistochemical markers were used to subtype 1,424 cases of invasive and in situ breast cancer, and case subtypes were compared to 2,022 controls. Luminal A, the most common subtype, exhibited risk factors typically reported for breast cancer in previous studies, including inverse associations for increased parity and younger age at first full-term pregnancy. Basal-like cases exhibited several associations that were opposite to those observed for luminal A, including increased risk for parity and younger age at first term full-term pregnancy. Longer duration breastfeeding, increasing number of children breastfed, and increasing number of months breastfeeding per child were each associated with reduced risk of basal-like breast cancer, but not luminal A. Women with multiple live births who did not breastfeed and women who used medications to suppress lactation were at increased risk of basal-like, but not luminal A, breast cancer. Elevated waist-hip ratio was associated with increased risk of luminal A in postmenopausal women, and increased risk of basal-like breast cancer in pre- and postmenopausal women. The prevalence of basal-like breast cancer was highest among premenopausal African-American women, who also showed the highest prevalence of basal-like risk factors. Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity. IS - 1 JF - Breast Cancer Research and Treatment SN - 1573-7217 EP - 139 TI - Epidemiology of basal-like breast cancer VL - 109 SP - 123 KW - basal KW - breast KW - cancer KW - carolina KW - superlist KW - thelist AU - Millikan, Robert AU - Newman, Beth AU - Tse, Chiu-Kit AU - Moorman, Patricia AU - Conway, Kathleen AU - Smith, Lisa AU - Labbok, Miriam AU - Geradts, Joseph AU - Bensen, Jeannette AU - Jackson, Susan AU - Nyante, Sarah AU - Livasy, Chad AU - Carey, Lisa AU - Earp, Shelton AU - Perou, Charles PY - 2007/06/20/ UR - http://dx.doi.org/10.1007/s10549-007-9632-6 ER -