Linking within- and between-host dynamics in the evolutionary epidemiology of infectious diseases Export

@article{citeulike:3498278, abstract = {Nested models (also called embedded models) explicitly link dynamical processes that occur at different scales. Recently there has been considerable interest in linking within- and between-host levels of disease dynamics in the study of pathogen evolution. Here we review the extent to which these nested models have increased our understanding of pathogen evolution. We suggest that, although such models have been useful for determining the nature of tradeoffs between epidemiological parameters and for evaluating the consequences of conflicting selection pressures at different scales, the vast majority of previous results could likely have been obtained without the use of nested models per se. Nevertheless, these models have proven very useful through their highlighting of the importance of within-host disease dynamics on pathogen evolution}, author = {Mideo, N. and Alizon, S. and Day, T.}, citeulike-article-id = {3498278}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tree.2008.05.009}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0169534708002188}, doi = {10.1016/j.tree.2008.05.009}, issn = {01695347}, journal = {Trends in Ecology \& Evolution}, keywords = {epidemiology, evolution, host, infectious, read}, month = {September}, number = {9}, pages = {511--517}, posted-at = {2008-11-09 15:03:11}, priority = {2}, title = {Linking within- and between-host dynamics in the evolutionary epidemiology of infectious diseases}, url = {http://dx.doi.org/10.1016/j.tree.2008.05.009}, volume = {23}, year = {2008} }

TY - JOUR ID - citeulike:3498278 L3 - citeulike-article-id:3498278 N2 - Nested models (also called embedded models) explicitly link dynamical processes that occur at different scales. Recently there has been considerable interest in linking within- and between-host levels of disease dynamics in the study of pathogen evolution. Here we review the extent to which these nested models have increased our understanding of pathogen evolution. We suggest that, although such models have been useful for determining the nature of tradeoffs between epidemiological parameters and for evaluating the consequences of conflicting selection pressures at different scales, the vast majority of previous results could likely have been obtained without the use of nested models per se. Nevertheless, these models have proven very useful through their highlighting of the importance of within-host disease dynamics on pathogen evolution IS - 9 JF - Trends in Ecology & Evolution SN - 01695347 EP - 517 TI - Linking within- and between-host dynamics in the evolutionary epidemiology of infectious diseases VL - 23 SP - 511 KW - epidemiology KW - evolution KW - host KW - infectious KW - read AU - Mideo, N AU - Alizon, S AU - Day, T PY - 2008/09// UR - http://dx.doi.org/10.1016/j.tree.2008.05.009 ER -