Prolactin, dendritic cells, and systemic lupus erythematosus Export

@article{citeulike:3517947, abstract = {Dendritic cells (DC) play a central role in the induction of autoimmunity in T and B cells. DC express a high level of the major histocompatibility complex that interact with the receptors on T cells. Immature DC present antigens efficiently. Prolactin (PRL) participates in DC maturation. Systemic lupus erythematosus (SLE) is characterized by a loss of tolerance to self-antigens and persistent production of autoantibodies. Serum from SLE patients induces normal monocytes to differentiate into DC in correlation with disease activity depending on the actions of interferon-\&\#x3b1;, immune complexes, PRL, etc. High serum PRL levels have been found in a subset of SLE patients associated with active disease and organ involvement. It is possible that PRL interacts with DC, skewing its function from antigen presentation to a proinflammatory phenotype with high interferon-\&\#x3b1; production. Therefore, SLE is characterized by deficiency of DC functions and abnormal PRL secretion. The relationships between PRL and DC may have a role in the pathogenesis of SLE.}, author = {Jara, L. and Benitez, G. and Medina, G.}, citeulike-article-id = {3517947}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.autrev.2007.11.018}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1568997207001772}, doi = {10.1016/j.autrev.2007.11.018}, issn = {15689972}, journal = {Autoimmunity Reviews}, keywords = {cell, confounder, dendritic, hormone, prolactin, sle, superlist, thelist}, month = {January}, number = {3}, pages = {251--255}, posted-at = {2008-11-15 02:29:48}, priority = {2}, title = {Prolactin, dendritic cells, and systemic lupus erythematosus}, url = {http://dx.doi.org/10.1016/j.autrev.2007.11.018}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:3517947 L3 - citeulike-article-id:3517947 N2 - Dendritic cells (DC) play a central role in the induction of autoimmunity in T and B cells. DC express a high level of the major histocompatibility complex that interact with the receptors on T cells. Immature DC present antigens efficiently. Prolactin (PRL) participates in DC maturation. Systemic lupus erythematosus (SLE) is characterized by a loss of tolerance to self-antigens and persistent production of autoantibodies. Serum from SLE patients induces normal monocytes to differentiate into DC in correlation with disease activity depending on the actions of interferon-α, immune complexes, PRL, etc. High serum PRL levels have been found in a subset of SLE patients associated with active disease and organ involvement. It is possible that PRL interacts with DC, skewing its function from antigen presentation to a proinflammatory phenotype with high interferon-α production. Therefore, SLE is characterized by deficiency of DC functions and abnormal PRL secretion. The relationships between PRL and DC may have a role in the pathogenesis of SLE. IS - 3 JF - Autoimmunity Reviews SN - 15689972 EP - 255 TI - Prolactin, dendritic cells, and systemic lupus erythematosus VL - 7 SP - 251 KW - cell KW - confounder KW - dendritic KW - hormone KW - prolactin KW - sle KW - superlist KW - thelist AU - Jara, L AU - Benitez, G AU - Medina, G PY - 2008/01// UR - http://dx.doi.org/10.1016/j.autrev.2007.11.018 ER -